Ceftazidime

• CAS: 78439-06-2
• Catalog Number: ACM78439062
• Category: Main Products
• Molecular Weight: 636.65
• Molecular Formula: C₂₂H₃₂N₆O₁₂S₂
• Synonyms: 1-[[(6r,7r)-7-[[(2z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl]methyl]pyridinum hydroxide inner salt;1-[[(6R,7R)-7-[[(2Z)-(2-AMINO-4-THIAZOLYL)[(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL]AMINO]-2-CARBOXY-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-EN-3-YL]METHYL]PYRIDINUM PENTAHYDRATE;CEFTAZIDIME PENTAHYDRATE;cazpentahydrate;gr20263pentahydrate;innersalt,(6r-(6-alpha,7-beta(z)))-droxidpentahydrate;sn401pentahydrate;CEFTAZIME
• IUPAC Name: ceftazidime pentahydrate
• Melting Point: >1500C (dec.)
• Appearance: White to off-white crystalline powder
• Exact Mass: 546.09900
• Hazard Statements: Xn
• Safety Description: 22-36/37-45-37-24
• Supplemental Hazard Statements: H315-H317-H319-H334-H335
• Symbol: GHS07,GHS08

Case Study

Ceftazidime Used for Mitigating A. baumannii Infections and Assessing Sub-MIC Implications

Yadav B, et al. Microbial Pathogenesis, 2025, 199, 107229.

Ceftazidime (CAZ) is extensively prescribed for treating Acinetobacter baumannii-induced infections, particularly nosocomial pneumonia in immunocompromised patients. This study investigated the effects of sub-minimum inhibitory concentrations (sub-MICs) of CAZ on the A. baumannii KSK1 strain, a pathogen of critical concern due to its antibiotic resistance and biofilm-forming capability.
The minimum inhibitory concentration (MIC) of CAZ was determined via the broth microdilution method, following CLSI protocols. A series of two-fold dilutions (16 mg/mL to 15 μg/mL) were tested against A. baumannii KSK1 in triplicates, and the lowest concentration preventing visible bacterial growth after 24 hours at 37 °C was designated as the MIC. Sub-MIC concentrations demonstrated multiple impacts: (1) reduced adhesion to lung epithelial cells, slowing bacterial growth temporarily; (2) altered bacterial cell morphology, leading to aggregation resembling biofilm structures; and (3) promoted in vitro biofilm formation, a key factor in bacterial persistence and resistance.
The findings highlight CAZ's dual role: while effective against A. baumannii at therapeutic concentrations, sub-MIC levels in environmental settings, such as wastewater, may inadvertently select for biofilm formation and antibiotic resistance.

Custom Q&A

What is the molecular formula of ceftazidime?

The molecular formula of ceftazidime is C22H22N6O7S2.

What are some synonyms for ceftazidime?

Some synonyms for ceftazidime include Tazidime, Fortaz, Pentacef, Tazicef, and Ceptaz.

What is the chemical safety classification of ceftazidime?

Ceftazidime is classified as an irritant and a health hazard.

What is the structure of ceftazidime?

The structure of ceftazidime can be seen in the provided images Ceftazidime2d.png and Ceftazidime3d.png.

What is the CAS number for ceftazidime?

The CAS number for ceftazidime is 72558-82-8.

What are some trade names for ceftazidime?

Some trade names for ceftazidime include Fortum, Modacin, and Fortam.

What is the INN (International Nonproprietary Name) for ceftazidime?

The INN for ceftazidime is Ceftazidime.

What is the chemical formula for ceftazidime in anhydrous form?

The chemical formula for ceftazidime in anhydrous form is C22H22N6O7S2.

What is the molecular weight of ceftazidime?

The molecular weight of ceftazidime is approximately 546.58 g/mol.

What is the therapeutic classification of ceftazidime?

The therapeutic classification of ceftazidime is J01DD07.