3-[18-(2-carboxyethyl)-7,12-bis(1,2-dihydroxyethyl)-3,8,13,17-tetramethyl-1,2,3,12,13,14-hexahydroporphyrin-21,22,23,24-tetraid-2-yl]propanoic acid;zinc

Name: 3-[18-(2-carboxyethyl)-7,12-bis(1,2-dihydroxyethyl)-3,8,13,17-tetramethyl-1,2,3,12,13,14-hexahydroporphyrin-21,22,23,24-tetraid-2-yl]propanoic acid;zinc
SKU: ACM119700811
Rating: 5 (1 reviews)

CAS

119700-81-1

Catalog Number

ACM119700811

Category

Main Products

Molecular Weight

694.06

Molecular Formula

C34H36N4O8Zn

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Specification

Synonyms

zinc deuteroporphyrin IX 2,4-bis(glycol)

Appearance

Solid

Zinc Deuteroporphyrin IX 2,4-Bis(Glycol) Used to Investigate the Role of HO-1 in the Resistance of Ischemic Brain to Oxidative Stress

Yoo S J, et al. Endocrinology and metabolism, 2014, 29(3), 356.

Since biliverdin and bilirubin produced by heme oxygenase isoform 1 (HO-1) have antioxidant properties, these two antioxidants produced by HO-1 may contribute to the resistance of ischemic brain tissue to oxidative stress.
· To confirm the role of HO-1, carbon monoxide, and cyclic guanosine monophosphate in the antioxidant effects of HO-1 and bilirubin, cells were treated with cycloheximide (20 ng/mL), desferoxamine (5 nM), and zinc deuteroporphyrin IX 2,4-bis(glycol) (ZnBG, 20 µM), respectively, in the induction phase of the experiment for 1 hour.
· The results showed that HO-1 is an antioxidant in its own right. HO-1 requires heme and iron to produce the observed survival effects. However, bilirubin, as an effector of HO-1 oxidative stress, does not require CO or cGMP. Furthermore, HO-1 activity also plays an important role in providing bilirubin as an antioxidant.

Zinc Deuteroporphyrin IX 2,4-Bis(Glycol) Used to Study the Mechanism of Antinociception Induced by Acute Stress

Carvalho-Costa P G, et al. Brazilian Journal of Medical and Biological Research, 2014, 47, 1057-1061.

Endogenous carbon monoxide (CO) is produced by heme oxygenase (HO), which acts as a neuromodulator involved in physiological processes such as thermoregulation and pain perception by stimulating the formation of 3',5'-cyclic guanosine monophosphate (cGMP). In this work, the analgesia index (AI) in the rat tail-flick test was used to evaluate the role of the HO-CO-cGMP pathway in acute stress-induced analgesia, and zinc deuteroporphyrin IX 2,4-bis(glycol)(ZnDPBG) was selected as a non-selective inhibitor of HO.
Results related to ZnDPBG
· The AIs of group 1, which received icv administration of ZnDPBG, and group 2, which received Na2CO3 as a vehicle, showed significant differences over time [F(8,143)=26.76, P<0.001] and due to treatment [F(1,143)=12.97, P<0.001], but there was no interaction between time and treatment [F(8,143)=0.37, P=0.94].
· The post-hoc Newman-Keuls test indicated that the AIs in the ZnDPBG and Na2CO3 groups were significantly different (P<0.05) at all experimental times compared to their respective baseline values (P<0.05, Newman-Keuls test).
· The results showed that acute stress-induced analgesia was independent of the HO-CO-cGMP pathway, as neither the HO inhibitor ZnDBPG nor heme lysine salts altered AI.