Original Article:
Revolutionary advances in 2-methacryloyloxyethyl phosphorylcholine polymers as biomaterials
Kazuhiko Ishihara
Journal of Biomedical Materials Research Part A, 2019, 107(5): 933-943.
10.1002/jbm.a.36635
In this review, the researchers describe the development of one such polymer composed of 2-methacryloyloxyethylphosphorylcholine units and provide specific examples for use in biomedical devices.
The development process of MPC and its polymer is shown in the figure. Subsequently, a variety of MPC polymer synthesis methods have been developed, including:
> Copolymerization of MPC with other vinyl compounds was also systematically investigated by conventional or advanced living radical polymerization into various architectures, such as block-type and graft-type copolymers.
> Surface-initiated living radical polymerization of MPC was also demonstrated to form polymer brushes with unique properties arising from the high density of polymer graft chains.
> Typically, MPC copolymerizes efficiently with styrene and with various alkyl methacrylates such as nbutyl methacrylate (BMA), n-hexyl methacrylate, n-dodecyl methacrylate (DMA), or n-stearyl methacrylate, resulting in polymers with statistically random sequence.
In addition, the applications of MPC polymers in biomedical devices include guide wire, stent, drug eluting stent, artificial lung (oxygenator), microcatheter, catheter, artificial heart (LVAD), contact lens, tympanostomy tube, artificial hip joint, etc.
Chemicals Related in the Paper:
| Catalog Number | Product Name | Structure | CAS Number | Price |
|---|---|---|---|---|
| ACM67881985-2 | 2-Methacryloyloxyethyl phosphorylcholine |  |
67881-98-5 | Price |
