Original Article:
A new nano-Fe3O4-supported organocatalyst based on 3,4-dihydroxypyridine: an efficient heterogeneous nanocatalyst for one-pot synthesis of pyrazolo[3,4-b]pyridines and pyrano[2,3-d]pyrimidines
Mozhgan Pirhayati, et al.
Appl. Organometal. Chem., 2016, 30(12), 1004-1008.
10.1002/aoc.3534
The development of recyclable organocatalysts with high catalytic performance is the main topic of many current studies. The preparation of solid-supported organocatalysts may be a very useful approach to obtain more efficient catalytic systems for the synthesis of fine chemicals under particularly simple and mild conditions. It has been reported that pyridine is one of the most widely used materials supported on solid substrate organocatalysts.
Because nano Fe3O4 has unique physical properties, such as high surface area, excellent thermal and chemical stability, low toxicity and magnetic properties. In this work, Fe3O4 was used as a promising support for the heterogeneous 3,4-dihydroxypyridine (Py) to prepare novel magnetically recyclable heterogeneous catalysts as shown. The results showed that the obtained Fe3O4/Py nanoparticles are an effective base catalyst. It can be used for the domino condensation of various aromatic aldehydes, Meldrum acids and 5-methylpyrazol-3-amine under very mild reaction conditions and in the presence of ethanol solvents. In addition, the catalyst was reused five times without significant degradation in catalytic activity and performance.
Chemicals Related in the Paper:
| Catalog Number | Product Name | Structure | CAS Number | Price |
|---|---|---|---|---|
| ACM10182486 | 3,4-Dihydroxypyridine |  |
10182-48-6 | Price |
