Sulindac

• CAS: 38194-50-2
• Catalog Number: ACM38194502
• Category: Other Products
• Molecular Weight: 356.41
• Molecular Formula: C20H17FO3S
• Synonyms: SULINOL;SULINDAC;SULREUMA;MK-231;(z)-5-fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1h-indene-3-ac;1h-indene-3-aceticacid,5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methyle;Aclin;arthrocine
• Melting Point: 182-185°C
• Flash Point: 305.6°C
• Density: 1.38 g/cm³
• Solubility: water, 16.89 mg/L @ 25 °C (est)
• Appearance: Yellow solid
• Assay: 0.99
• EC Number: 253-819-2
• Hazard Statements: Xn
• MDL Number: MFCD00599589
• Packaging: 1 kg
• Refractive Index: 1.672
• Stability: Stable at normal temperatures and pressures.
• Storage Conditions: Keep tightly closed.
• Supplemental Hazard Statements: H301-H317-H334-H361
• Symbol: GHS06,GHS08

Custom Q&A

What is the molecular formula of sulindac?

The molecular formula of sulindac is C20H17FO3S.

What is the molecular weight of sulindac?

The molecular weight of sulindac is 356.4 g/mol.

What is the role of sulindac as described in the reference?

Sulindac has a role as a non-steroidal anti-inflammatory drug, an antineoplastic agent, an analgesic, a prodrug, a tocolytic agent, and an apoptosis inducer.

How is sulindac categorized in terms of chemical structure?

Sulindac is categorized as a sulfoxide, monocarboxylic acid, and organofluorine compound.

How is sulindac metabolized in the body?

Sulindac is a prodrug that is converted to an active sulfide compound by liver enzymes in vivo.

What is the brand name under which sulindac is marketed?

Sulindac is marketed by Merck under the brand name Clinoril.

What is the mechanism of action of sulindac as described in the DrugBank reference?

The mechanism of action of sulindac is as a Cyclooxygenase Inhibitor.

What is the InChIKey of sulindac?

The InChIKey of sulindac is MLKXDPUZXIRXEP-MFOYZWKCSA-N.

How is sulindac mostly thought to mediate its action?

Sulindac is mostly thought to mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.

What are some synonyms for sulindac?

Some synonyms for sulindac include Arthrocine and Sulindacum.

Synthetic Use

Upstream Synthesis Route 1

• 49627-27-2

• 38194-50-2

Reference: [1] Patent: EP1466897, 2004, A1, . Location in patent: Page 5

Upstream Synthesis Route 2

• 298-12-4
• 41201-62-1

• 38194-50-2

Reference: [1] Synlett, 2001, # 1, p. 41 - 44

Upstream Synthesis Route 3

• 41201-60-9

• 38194-50-2

Reference: [1] Synlett, 2001, # 1, p. 41 - 44

Downstream Synthesis Route 1

• 38194-50-2

• 292617-18-6

Reference: [1]Pharmacy and Pharmacology Communications,2000,vol. 6,p. 217 - 221

* For details of the synthesis route, please refer to the original source to ensure accuracy.