Semduramicin

• CAS: 113378-31-7
• Catalog Number: ACM113378317
• Category: Main Products
• Molecular Weight: 873.079
• Molecular Formula: C₄₅H₇₆O₁₆
• Synonyms: Semduramicin;Semduramycin;2H-Pyran-2-acetic acid, tetrahydro-2,4-dihydroxy-6-(1R)-1-(2S,5R,7S,8R,9S)-9-hydroxy-2,8-dimethyl-2-(2S,2R,3S,5R,5R)-octahydro-2-methyl-5-(2S,3S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl-3-(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-;UK-61689
• IUPAC Name: Semduramicin
• Boiling Point: 921.3ºC at 760mmHg
• Flash Point: 262.8ºC
• Density: 1.27g/cm³
• Exact Mass: 872.51300

Case Study

Application of Semduramicin in Poultry Feed and Its Detection Method

Vincent, Ursula, et al. Journal of pharmaceutical and biomedical analysis, 2012, 61, 150-155.

Semduramicin (Aviax) is an ionophore coccidiostat licensed as a fattening feed additive for chickens. In order to determine whether feed samples comply with legal requirements and to check whether the labeling is correct, an efficient method based on liquid chromatography, UV spectrophotometric detection and post-column derivatization (LC-UV-PCD) was proposed.
Preparation of test samples containing semduramicin
· Compound feed samples: Specifically, 25 ± 0.1 g of the compound feed samples were spiked with varying amounts of Aviax 5%. These amounts were chosen to align with the authorized concentration of semduramicin in the feed additive, resulting in concentrations of 12.8 mg kg-1, 25.7 mg kg-1, and 51.3 mg kg-1. Additionally, the samples were fortified with a mixture of other coccidiostats to ensure proper penetration into the feed matrix before further analysis.
· Premixtures: In another set of experiments, premixture samples that did not contain semduramicin were mixed with Aviax 5%, leading to a dilution of the target compound. To validate the process, these premixture samples were spiked with appropriate amounts of Aviax 5% to achieve a target concentration of semduramicin of 3.07 g kg-1 in the premixture.
· Feed additive: As for the feed additive Aviax 5%, it was used as is without any additional treatment. The specific target concentration of semduramicin in the feed additive was 51.3 g kg-1 according to the relevant regulations.

Custom Reviews

August 18, 2023

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Supply chain integrity
Semduramicin's inventory is sufficient and can be repurchased at any time.

Custom Q&A

What kind of compound is semduramicin?

As a kind of polyether ion carrier, semduramicin can form a complex with metal ions, thus affecting the ion permeability of cell membrane.

What is the main purpose of semduramicin?

The main use of semduramicin is as an anti-coccidiosis drug, which is used to prevent and treat coccidiosis caused by coccidia in chickens.

What is the molecular formula and molecular weight of semduramicin?

The molecular formula of semduramicin is C45H75O16Na, and its molecular weight is 894.51 g/mol.

How much does semduramicin inhibit Eimeria tenella?

Semduramicin has a strong inhibitory effect on Eimeria tenella, and its IC50 is 30.0 ng/mL.

What is the recommended dose of semduramicin in feed?

The recommended dosage of semduramicin in feed is 20-25 mg/kg.

What are the physical and chemical properties of semduramicin?

Semduramicin is a white or white-like powder, insoluble in water, slightly soluble in ethanol, soluble in chloroform and toluene.

What is the future development direction and application prospect of semduramicin?

Semduramicin can be used in combination with other anticoccidial drugs to improve curative effect and reduce drug resistance. In addition, A can also be used for the prevention and treatment of coccidiosis in other animal species.

What effect does semduramicin have on bacteria?

Semduramicin is incompatible with some other drugs, such as timycin, and drug interaction will occur between them, leading to serious toxic reactions.

What percentage of sodium does semduramicin contain?

Semduramicin contains about 2.8% sodium.