PYRANTEL TARTRATE SALT

• CAS: 33401-94-4
• Catalog Number: ACM33401944
• Category: Main Products
• Molecular Weight: 356.39
• Molecular Formula: C15H20N2O6S
• Synonyms: Pyrantel (+)-tartrate salt,1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine
• Appearance: Solid

Case Study

Pyrantel pamoate resistance study in horses treated with pyrantel tartrate daily

Brazik, Emily L., Jan T. Luquire, and Dianne Little. Journal of the American Veterinary Medical Association 228.1 (2006): 101-103.

Sixteen horses were treated with pyrantel tartrate (2.64 mg/kg [1.2 mg/lb], PO) daily as part of a preventive deworming program. Effective control of strongyle nematodes in horses has become increasingly difficult as anthelmintic resistance becomes more common. Only three drug groups, benzimidazoles, avermectins, and pyrantel salts, are effective against cyathostomes. Resistance to benzimidazoles is common, and resistance to avermectins is becoming increasingly common, especially in the southeastern United States. Resistance to macrolides has not been reported. Pyrantel tartrate PO at a dose of 2.64 mg/kg (1.2 mg/lb) daily has been promoted as a means of controlling cyathostome infections in horses. However, there is concern that this practice may be associated with the development of cyathostomes resistant to pyrantel pamoate at a dose of 6.6 mg/kg (3 mg/lb).
FWEC reduction testing was initiated the day after fecal worm egg counts (FWECs) were obtained; all horses with FWECs > 100 epg (9 horses) were treated with pyrantel pamoate (6.6 mg/kg [3 mg/lb], PO), and 14 days later, the FWEC was repeated. During the 14-day period, all horses received pyrantel tartrate (2.64 mg/kg, PO) daily. The reduction in fecal worm egg counts was calculated for each horse. The mean FWEC reduction for this group was 28.5% (range, 21% increase in FWECs 14 days after treatment to 100% decrease in FWECs 14 days after treatment).

Bioequivalence controlled efficacy study of pyrantel tartrate in horses

Valdez, Reginald A., et al. Veterinary parasitology 60.1-2 (1995): 83-102.

The bioequivalence of Strongid and genetic pyrantel tartrate was established in a controlled study using 30 horses with naturally acquired endoparasitic infections. Three horses were randomly assigned to each of 10 replicates based on quantitative nematode and ascarid egg counts and fecal larval culture results. Horses within each replicate were randomly assigned to one of three treatment groups. Horses in treatment group 1 received oats only; horses in treatment group 2 received generic pyrantel tartrate granules (mixed with oats; horses in treatment group 3 were fed Strongid granules mixed with oats. Horses were treated daily for 30 days. At the end of the study, horses were necropsied, and internal parasites were recovered, identified, and enumerated. In all cases, there was no significant difference in the mean number of parasites recovered between horses treated with generic pyrantel tartrate and horses treated with Strongid. The number of gastrointestinal parasites recovered from horses treated with generic pyrantel tartrate or Strongid showed significant differences from the number of gastrointestinal parasites recovered from untreated controls.
Paddocks were cleaned thoroughly and fresh straw bedding was provided 3 times per week. All animals in the study received the same ration; each horse was fed 0.5 L of oats once daily individually and had ad libitum access to trace mineralized salts, fresh water, and alfalfa hay. During the acclimation period and on study days 0, 10, 20, and 30 Individual animal body weights were recorded once daily. Body weights were used to calculate the exact dose of genetic pyrantel tartrate and Strongid pellets for each horse throughout the study.

Effect of pyrantel tartrate on population dynamics and performance parameters in young horses repeatedly infested with Strongylin nematodes

Reinemeyer, C. R., et al. Veterinary Parasitology 204.3-4 (2014): 229-237.

Strongyloid nematode infections are prevalent in grazing horse populations. Cyathostomin (small strongylin) and strongylin (large strongylin) nematode infections have long been associated with clinical disease in horses. A blinded, randomized, controlled study was conducted to evaluate the effects of daily administration of pyrantel tartrate on body condition scores, weight gain, fecal egg counts, and total worm counts in young horses repeatedly inoculated with Strongylin larvae. Daily treatment with pyrantel tartrate at the recommended dose significantly reduced the number of imaginal worms in the intestinal lumen and the number of early third-stage larvae in the cecal mucosa, increased the proportion of fourth-stage larvae in the intestinal contents, and was accompanied by significant improvements in body condition scores. Fecal egg counts were significantly reduced in horses treated daily with pyrantel tartrate, with percentage efficacy ranging from 84.4% to 98.9%, but egg counts increased significantly in both groups over the course of the study.
Twenty-eight immature horses were treated with a larvicidal deworming regimen and randomized into two groups. Group 1 horses were given a pelleted placebo product once daily, and Group 2 horses received cyathostomide tartrate at approximately 2.64 mg/kg body weight once daily. ~5000 infective cyathostomide larvae were administered to each horse 5 days per week. In addition, horses received ~25 infective Strongylus vulgaris larvae once weekly. Horses were housed on pasture for 154 days and had ad libitum access to grass hay throughout. Approximately every 14 days, body weight was measured, body condition scores were assigned, fecal samples were collected for egg counts, and blood samples were collected for measurement of S. vulgaris antibodies and various physiological parameters.

Effect of pyrantel tartrate on Sarcocystis neurona merozoites

Kruttlin, Elizabeth A., et al. Veterinary Therapeutics 2.3 (2001): 268-276.

Sarcocystis neurona is the causative agent of equine protozoan myeloencephalitis, a neurological disease of horses. Studies were designed to test the hypothesis that pyrantel tartrate can kill S. neurona merozoites grown in equine dermal cell cultures. Sarcocystis neurona merozoites were exposed to a range of concentrations of pyrantel or sodium tartrate from 0.001 to 0.01 M. Magnetozoites were then plated onto equine dermal cell cultures and incubated for 2 weeks to examine viability. Plaque counts were compared between treatments and between treatments and controls at 1 and 2 weeks post-inoculation. Magnetozymes exposed to concentrations of pyrantel tartrate above 0.0025 M (8.91 × 10 g/ml) did not produce plaques in horse dermal cells, whereas those exposed to similar concentrations of tartrate or medium alone produced numerous plaques. These results demonstrate that pyrantel tartrate is active against S. neurona merozoites in vitro and suggest that it may be active against sporozoite stages of the parasite found in the equine intestine.
Pyrantel tartrate was tested as a possible preventive measure for EPM, and sodium tartrate was used as a salt control. A 0.1 M solution of pyrantel tartrate in DMEM was filtered through a 0.22 μm filter to remove contaminants and diluted in DMEM to concentrations of 0.01, 0.0075, 0.005, 0.0025, and 0.001 M. Filter a 0.1 M solution of sodium tartrate and DMEM through a 0.22 μm filter and dilute as above. For each drug, add 1.0 mL of each dilution to the 15 mL conical tube containing the merozoites. Add 1 ml of DMEM alone (pH 7.88) back into the other two tubes as a negative control.

Custom Q&A

What is the molecular weight of Pyrantel tartrate salt?

The molecular weight of Pyrantel tartrate salt is 356.4 g/mol.

What is the IUPAC name of Pyrantel tartrate salt?

The IUPAC name of Pyrantel tartrate salt is (2R,3R)-2,3-dihydroxybutanedioic acid;1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine.

How many hydrogen bond donor counts does Pyrantel tartrate salt have?

Pyrantel tartrate salt has 4 hydrogen bond donor counts.

How many hydrogen bond acceptor counts does Pyrantel tartrate salt have?

Pyrantel tartrate salt has 8 hydrogen bond acceptor counts.

How many rotatable bond counts does Pyrantel tartrate salt have?

Pyrantel tartrate salt has 5 rotatable bond counts.

What is the exact mass of Pyrantel tartrate salt?

The exact mass of Pyrantel tartrate salt is 356.10420754 g/mol.

What is the topological polar surface area of Pyrantel tartrate salt?

The topological polar surface area of Pyrantel tartrate salt is 159?2.

How many heavy atoms does Pyrantel tartrate salt have?

Pyrantel tartrate salt has 24 heavy atoms.

What is the formal charge of Pyrantel tartrate salt?

The formal charge of Pyrantel tartrate salt is 0.

How many defined atom stereocenter counts does Pyrantel tartrate salt have?

Pyrantel tartrate salt has 2 defined atom stereocenter counts.