Vacuolin-1

• CAS: 351986-85-1
• Catalog Number: ACM351986851
• Category: Inhibitors
• Molecular Weight: 577.42
• Molecular Formula: C₂₆H₂₄IN₇O
• Description: Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin-1 is a potent and selective PIKfyve inhibitor and inhibits late-stage autophagy by impairing lysosomal maturation.
• Canonical SMILES: IC1=CC(/C=N/NC2=NC(N(C3=CC=CC=C3)C4=CC=CC=C4)=NC(N5CCOCC5)=N2)=CC=C1
• Appearance: Solid
• Storage: -20°C, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen).
• Shipping: Can be shipped at room temperature, where not in use may vary.