Umibecestat free base

• CAS: 1387560-01-1
• Catalog Number: ACM1387560011
• Category: Inhibitors
• Molecular Weight: 513.80
• Molecular Formula: C19H15ClF7N5O2
• Description: Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP-transgenic mice
• Synonyms: Umibecestat; CNP-520; CNP 520; CNP520
• IUPAC Name: N-{6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl}-3-chloro-5-; (trifluoromethyl)pyridine-2-carboxamide
• Canonical SMILES: O=C(C1=NC=C(C(F)(F)F)C=C1Cl)NC2=NC([C@]3(C)CO[C@](C(F)(F)F)(C)C(N)=N3)=C(F)C=C2
• InChI: InChI=1S/C19H15ClF7N5O2/c1-16(7-34-17(2,15(28)32-16)19(25,26)27)13-10(21)3-4-11(30-13)31-14(33)12-9(20)5-8(6-29-12)18(22,23)24/h3-6H,7H2,1-2H3,(H2,28,32)(H,30,31,33)/t16-,17+/m0/s1
• InChI Key: PSBBWFNMHDUTRH-DLBZAZTESA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >3 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 1387560-01-1 (free base); 2365306-62-1 (HCl); 2365306-56-3 (fumarate); 2365306-58-5 (tatrate); 2365306-75-6 (citrate)
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 44.42; H, 2.94; Cl, 6.90; F, 25.88; N, 13.63; O, 6.23
• Exact Mass: 513.0802
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).