Topotecan-d6

• CAS: 1044904-10-0
• Catalog Number: ACM1044904100
• Category: Inhibitors
• Molecular Weight: 427.48
• Molecular Formula: C₂₃H₁₇D₆N₃O₅
• Description: Topotecan-d6 is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87.
• Synonyms: (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4',6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC-609669-d6; SKF-104864A-d6; Hycamtin-d6
• IUPAC Name: Topotecan-d6
• Canonical SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O
• InChI Key: UCFGDBYHRUNTLO-DPZAMXPDSA-N
• Appearance: Yellow Solid
• Storage: Powder-20°C, 3 years; In solvent-80°C. 6 months; -20°C, 1 month.
• Exact Mass: 427.20100
• Shipping: Can be shipped at room temperature, where not in use may vary.