Tizoxanide

• CAS: 173903-47-4
• Catalog Number: ACM173903474
• Category: Inhibitors
• Molecular Weight: 265.243
• Molecular Formula: C10H7N3O4S
• Description: Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells.
• Canonical SMILES: O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2O
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• MDL Number: MFCD07484970
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Size: 100mg,250mg,1g,5g,25g

Synthetic Use

Downstream Synthesis Route 1

• 541-41-3
• 173903-47-4

• 1259483-70-9

Reference: [1]Cao, Ruiyuan; Dai, Qingsong; Guo, Xiaojia; Li, Wei; Li, Xingzhou; Li, Yuexiang; Xia, Qing; Xu, Ke; Yan, Yunzheng; Yang, Jingjing; Yang, Keyu; Zhao, Lei; Zhong, Wu; Zou, Gang
[Antimicrobial Agents and Chemotherapy, 2020, vol. 64, # 7]
[2]Location in patent: experimental part
Stachulski, Andrew V.; Pidathala, Chandrakala; Row, Eleanor C.; Sharma, Raman; Berry, Neil G.; Iqbal, Mazhar; Bentley, Joanne; Allman, Sarah A.; Edwards, Geoffrey; Helm, Alison; Hellier, Jennifer; Korba, Brent E.; Semple, J. Edward; Rossignol, Jean-Francois
[Journal of Medicinal Chemistry, 2011, vol. 54, # 12, p. 4119 - 4132]

Downstream Synthesis Route 2

• 62965-35-9
• 173903-47-4

• 1928702-28-6

Reference: [1]Stachulski, Andrew V.; Swift, Karl; Cooper, Mark; Reynolds, Stephen; Norton, Daniel; Slonecker, Steven D.; Rossignol, Jean-François
[European Journal of Medicinal Chemistry, 2017, vol. 126, p. 154 - 159]
[2]Current Patent Assignee: ROMARK LABORATORIES, L.C. - WO2016/77420, 2016, A1
Location in patent: Page/Page column 35; 36

* For details of the synthesis route, please refer to the original source to ensure accuracy.