Thiolutin

• CAS: 1987-11-6
• Catalog Number: ACM1987116
• Category: Inhibitors
• Molecular Weight: 228.29
• Molecular Formula: C8H8N2O2S2
• Description: Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation.
• Canonical SMILES: CC(NC1=C2C(N(C)C1=O)=CSS2)=O
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: Streptomyces