Thiamine mononitrate

• CAS: 532-43-4
• Catalog Number: ACM532434
• Category: Main Products
• Molecular Weight: 327.36
• Molecular Formula: C₁₂H₁₇N₅O₄S
• Synonyms: Vitanon; Thiamin mononitrate; Vitamin B1 nitrate; Thiamine Nitrate; Thiaminnitrat; VitaMin B1 HNO3; Vitamin B1 Mono; Thaimenitrate; Thiaminenitrate; thiamine,nitrate; Thiamine nitrate,Vitamin B1 nitrate; mnitrate; thiamin nitrate; thiaminium nitrate
• IUPAC Name: Thiamine nitrate
• Melting Point: 196-200ºC
• Appearance: solid
• Application: Thiamine mononitrate, also known as Vitamin B1, is an essential nutrient required for carbohydrate metabolism and nerve function. It is commonly used as a dietary supplement in various food products such as crackers, egg substitutes, and enriched flour. Pharma laboratories and manufacturers can use certified pharmaceutical secondary standards of Thiamine Nitrate for quality control purposes, providing a convenient and cost-effective alternative to preparing in-house working standards.
• Exact Mass: 327.10000
• Safety Description: 22-24/25
• Stability: Stable. Incompatible with strong oxidizing agents.

Case Study

Crystallization and Stability of Thiamine in Thiamine Mononitrate

Arioglu-Tuncil, Seda, et al. International Journal of Molecular Sciences, 2020, 21(24), 9370.

Thiamine is an extremely unstable vitamin that is easily affected by external conditions such as heat, light, and alkaline pH. Thiamine mononitrate (TMN) is one of the common synthetic crystalline salt forms of thiamine. TMN has been widely used in foods and dietary supplements for concentration and fortification purposes. For example, TMN is commonly used to enrich dry foods, including flour, as well as vitamin tablets and dietary supplements.
The degradation of thiamine in thiamine mononitrate (TMN) polymer solid dispersions was studied. The results indicate that thiamine is less stable when present at low proportions in solid dispersions than at higher proportions. Additionally, thiamine is most stable in its crystalline form and less stable in its amorphous form.
Preparation of TMN solid dispersion
· TMN Polymer dispersions were prepared by lyophilizing solutions containing TMN and amorphous polymers (pectin and PVP (polyvinylpyrrolidone)).
· Samples were stored for eight weeks in a controlled temperature and relative humidity (RH) environment and monitored regularly by X-ray diffraction and high-performance liquid chromatography (HPLC).

Custom Q&A

What is the molecular formula of thiamine mononitrate?

The molecular formula of thiamine mononitrate is C12H17N5O4S.

What are the synonyms of thiamine mononitrate?

The synonyms of thiamine mononitrate are thiamine nitrate, Vitamin B1 nitrate, and Vitamin B1 mononitrate.

What is the molecular weight of thiamine mononitrate?

The molecular weight of thiamine mononitrate is 327.36 g/mol.

What is the chemical structure of thiamine mononitrate?

The chemical structure of thiamine mononitrate can be viewed at the following link: [https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=10762&t=s]

What is the IUPAC name of thiamine mononitrate?

The IUPAC name of thiamine mononitrate is 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol; nitrate.

What is the InChI of thiamine mononitrate?

The InChI of thiamine mononitrate is InChI=1S/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1.

What is the InChIKey of thiamine mononitrate?

The InChIKey of thiamine mononitrate is UIERGBJEBXXIGO-UHFFFAOYSA-N.

What is the CAS number of thiamine mononitrate?

The CAS number of thiamine mononitrate is 532-43-4.

What is the hydrogen bond donor count of thiamine mononitrate?

The hydrogen bond donor count of thiamine mononitrate is 2.

What is the hydrogen bond acceptor count of thiamine mononitrate?

The hydrogen bond acceptor count of thiamine mononitrate is 8.