tert-Butyl(chloro)diphenylsilane

• CAS: 58479-61-1
• Catalog Number: ACM58479611-8
• Category: Silylation Reagents
• Molecular Weight: 274.86
• Molecular Formula: C16H19ClSi
• Boiling Point: 90 °C/0.01 mmHg (lit.)
• Density: 1.057 g/mL at 25 °C (lit.)
• Application: Tert-Butyl(chloro)diphenylsilane serves as a highly effective silylating reagent primarily utilized for protecting primary and secondary alcohols through the formation of TBDPS ethers It demonstrates significant utility in organic synthesis and pharmaceutical applications by facilitating the conversion of alcohols into stable silyl ethers thus providing protection during complex chemical transformations This reagent achieves excellent yields quickly especially in reactions involving primary alcohols like benzyl alcohol in DMF where ammonium nitrate or ammonium perchlorate enhances the process Additionally tert-Butyl(chloro)diphenylsilane is instrumental in preparing crucial intermediates such as 1-benzyloxy-3-(tert-butyldiphenylsilyloxy)propan-2-ol which plays a vital role in the synthesis of mono-O-protected pyrimidine acyclic nucleosides Its application extends to the synthesis of interphenylene phenyloxazoles compounds beneficial for treating circulatory disorders angina and stroke highlighting its versatility and importance in both chemical synthesis and medicinal chemistry
• Physical State: Liquid