138-55-6 Purity
99%
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Specification
Sodium dodecyl sulfate (SDS) demonstrates significant effects on human transferrin (HTF), particularly regarding iron-binding capacity and structural integrity. Recent studies highlight SDS's capacity to bind tightly with HTF at a single binding site, characterized by strong binding constants and spontaneous interaction, as confirmed through isothermal titration calorimetry (ITC) data (ΔG = -40.1 kcal·mol⁻¹). This interaction disrupts the secondary structure of HTF and alters its conformation, leading to a dose-dependent release of bound iron ions.
Spectroscopic analysis further revealed that SDS distorts the microenvironment of aromatic amino acids within HTF, resulting in weakened iron-binding. Molecular docking has identified a distinct dual interaction mechanism: SDS's hydrophobic tail engages HTF through hydrophobic forces, while the hydrophilic head forms hydrogen bonds. These findings, aligned with ITC data, indicate that SDS disrupts HTF's stability and iron-carrying function through a concerted hydrophobic and hydrogen bonding process.
A polymer composite material with polyvinylidene fluoride (PVDF) as the matrix, zinc ferrite (ZnFe₂O₄, ZFO) as the ceramic filler, and sodium dodecyl sulfate (SDS) as a surface modifier was synthesized via a straightforward solvent-casting method for use in energy storage devices.
Synthesis of Zinc Ferrite (ZnFe₂O₄, ZFO) Nanoparticles
Zinc nitrate (Zn(NO₃)₂·6H₂O) and ferric nitrate (Fe(NO₃)₃·9H₂O) were combined at a molar ratio of 1:2 and dissolved in distilled water. Ethylenediaminetetraacetic acid (EDTA) was then added in molar ratios ranging from 1:1 to 1:5 with respect to the metal nitrates. The solution was mixed for 1 hour at room temperature using a magnetic stirrer. The mixture was heated to approximately 110°C until a black powder formed, which was then calcined at 750°C for 4 hours to obtain the ZFO nanopowder.
Synthesis of PVDF-ZFO-SDS Composite Film
First, PVDF was dissolved in DMF and stirred for 30 minutes. Separately, a designated amount of the synthesized ZFO nanopowder was dispersed in DMF, subjected to 1 hour of ultrasonic treatment to ensure uniform dispersion of the nanoparticles, and stirred for an additional 30 minutes. The PVDF and ZFO-DMF solutions were then combined and stirred for another 30 minutes to achieve a homogeneous solution. SDS was added to ZFO dispersed in DMF at various concentrations and stirred for 1 hour. In a separate flask, a PVDF-DMF mixture was stirred for 1 hour until a uniform, transparent solution formed. Finally, the solution containing SDS and ZFO was added to the PVDF solution. The complete mixture was sonicated and stirred for another 30 minutes before being poured into petri dishes and dried in a hot-air oven for 6 hours to produce the PVDF-ZFO-SDS composite film.
Sodium Dodecyl Sulfate (SDS) demonstrates significant promise in biomedical applications, particularly as a surfactant for effective protein removal from industrial-grade chitosan. The study under review explores a novel method utilizing an electric field in an SDS medium to achieve high-efficiency deproteinization of chitosan, producing material with a residual protein content as low as 0.151 wt%.
Using orthogonal experimental design, key parameters were optimized, including electric field intensity, SDS concentration, and electrophoresis duration. This design matrix (L9 (3^4)), with three factors-voltage (100 V, 300 V, 500 V), SDS concentration (0.1 wt%, 0.5 wt%, 1 wt%), and electrophoresis time (0.5 h, 1 h, 2 h)-determined that an optimal condition of 300 V, 1 wt% SDS, and a 2-hour treatment time yielded the highest protein removal efficiency. The efficiency is attributed to the strong electrostatic interaction between SDS molecules and residual proteins. SDS forms complexes with the proteins, imparting a negative charge that enables the migration of the SDS-protein complex under the electric field, thereby effectively separating it from the chitosan matrix.
The study highlights the potential of SDS in facilitating an effective, low-cost, and scalable method for chitosan deproteinization, positioning SDS as an essential reagent in enhancing the biomedical compatibility of industrial chitosan.
The molecular weight of Sodium Dodecyl Sulfate is 288.38 g/mol.
Sodium Dodecyl Sulfate has a role as a detergent and a protein denaturant.
Some synonyms for Sodium Dodecyl Sulfate include Sodium lauryl sulfate, Sodium dodecylsulfate, and Sodium lauryl sulphate.
The IUPAC Name of Sodium Dodecyl Sulfate is sodium;dodecyl sulfate.
The Canonical SMILES of Sodium Dodecyl Sulfate is CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+].
The CAS number for Sodium Dodecyl Sulfate is 151-21-3.
Sodium Dodecyl Sulfate appears as white to pale yellow paste or liquid with a mild odor.
Sodium Dodecyl Sulfate is used as a fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals, and toothpastes.
The molecular formula of Sodium Dodecyl Sulfate can be NaSO4C12H25, C12H25O4S.Na, or C12H25NaO4S.
Sodium Dodecyl Sulfate is used as a research tool in protein biochemistry.
The CAS number of Sodium Dodecyl Sulfate is 151-21-3.
Sodium Dodecyl Sulfate is used in cosmetics, pharmaceuticals, toothpastes, and as a research tool in protein biochemistry.
Sodium Dodecyl Sulfate appears as a white to pale yellow paste or liquid with a mild odor, and sinks and mixes with water.
The parent compound of Sodium Dodecyl Sulfate is Lauryl sulfate (CID 8778), and the component compounds are Lauryl sulfate (CID 8778) and Sodium (CID 5360545).
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* For details of the synthesis route, please refer to the original source to ensure accuracy.