Silver sulfadiazine

• CAS: 22199-08-2
• Catalog Number: ACM22199082
• Category: Inhibitors
• Molecular Weight: 357.14
• Molecular Formula: C10H9AgN4O2S
• Description: Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication.
• Synonyms: 4-Amino-n-2-pyrimidinylbenzenesulfonamide monosilver salt
• IUPAC Name: Silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
• Canonical SMILES: C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
• InChI: InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
• InChI Key: UEJSSZHHYBHCEL-UHFFFAOYSA-N
• Melting Point: 285 °C
• Appearance: White to off-white powder
• Application: Silver sulfadiazine serves as an antimicrobial agent used primarily for the prevention and treatment of wound infections in patients suffering from second- and third-degree burns. As a topical antibacterial, it is effective against various Gram-negative and Gram-positive bacteria, as well as yeast, helping to prevent microbial growth on damaged skin. Due to its highly insoluble nature, it does not lead to hypochloremia, unlike silver nitrate treatments. The cream should be continuously applied to the burned area throughout the healing process or until skin grafting occurs. Special care is advised when applying over large areas, as plasma sulfadiazine levels can potentially rise to therapeutic levels causing side effects. It is particularly beneficial against Pseudomonas species, notorious for complicating burn therapy. Silver sulfadiazine is favored for its ease of use compared to other burn treatments like dilute silver nitrate solutions or mafenide ointment, offering an effective solution without significant absorption into the body fluids.
• Storage: Keep in dark place,inert atmosphere,Room temperature
• Complexity: 327
• Covalently-Bonded Unit Count: 2
• EC Number: 244-834-5
• Exact Mass: 355.94971
• Formal Charge: 0
• H-Bond Acceptor: 6
• H-Bond Donor: 1
• Heavy Atom Count: 18
• Monoisotopic Mass: 355.94971
• Rotatable Bond Count: 3
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Topological Polar Surface Area: 95.3 Ų
• UNII: W46JY43EJR

Custom Q&A

What is the PubChem CID of silver sulfadiazine?

The PubChem CID of silver sulfadiazine is 441244.

What is the molecular formula of silver sulfadiazine?

The molecular formula of silver sulfadiazine is C10H9AgN4O2S.

What is the molecular weight of silver sulfadiazine?

The molecular weight of silver sulfadiazine is 357.14 g/mol.

What is the role of silver sulfadiazine?

Silver sulfadiazine has a role as an antimicrobial agent and an antibacterial drug.

What is the IUPAC name of silver sulfadiazine?

The IUPAC name of silver sulfadiazine is silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide.

What is the InChI of silver sulfadiazine?

The InChI of silver sulfadiazine is InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1.

What is the Canonical SMILES of silver sulfadiazine?

The Canonical SMILES of silver sulfadiazine is C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+].

What is the CAS number of silver sulfadiazine?

The CAS number of silver sulfadiazine is 22199-08-2.

What is the FDA Pharm Classes of silver sulfadiazine?

The FDA Pharm Classes of silver sulfadiazine are Sulfonamide Antibacterial.

What is the Wikipedia page for silver sulfadiazine?

The Wikipedia page for silver sulfadiazine is "Silver_sulfadiazine".