Sennoside A

• CAS: 81-27-6
• Catalog Number: ACM81276-1
• Category: Inhibitors
• Molecular Weight: 862.75
• Molecular Formula: C42H38O20
• Description: Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia). Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication.
• Synonyms: 4,4',10,10'-Tetrahydroxy-5,5'-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[9,9'-bianthracene]-2,2'-dicarboxylic acid
• IUPAC Name: (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
• Canonical SMILES: C1=CC2=C(C(=C1)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=O)C4=C([C@@H]2[C@@H]5C6=C(C(=CC=C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
• InChI: InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
• InChI Key: IPQVTOJGNYVQEO-KGFNBKMBSA-N
• Melting Point: >191 °C
• Density: 1.743±0.06 g/ml
• Appearance: Yellow solid
• pKa: 3.31±0.40

Synthetic Use

Downstream Synthesis Route 1

• 81-27-6

• 517-44-2
• 82334-26-7
• 517-44-2

Reference: [1]Chemical and Pharmaceutical Bulletin,1982,vol. 30,p. 1338 - 1346
[2]Chemical and Pharmaceutical Bulletin,1982,vol. 30,p. 1338 - 1346

Downstream Synthesis Route 2

• 81-27-6

• 480-09-1

Reference: [1]Chemical and Pharmaceutical Bulletin,1982,vol. 30,p. 1338 - 1346
[2]Chemical and Pharmaceutical Bulletin,1982,vol. 30,p. 1338 - 1346

* For details of the synthesis route, please refer to the original source to ensure accuracy.