PY-60

• Catalog Number: ACMA00019607
• Category: Activators
• Molecular Weight: 313.38
• Molecular Formula: C16H15N3O2S
• Description: PY-60 is a novel activator of YAP, promoting expansion of epidermal keratinocytes ex vivo and in vivo, targeting ANXA2 to activate YAP, activating a robust, YAP- dependent transcriptional program in multiple cell types. Chemical proteomics revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates with YAP at the cell membrane in response to increased cell density. PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP.
• Synonyms: PY-60; PY 60; PY60
• IUPAC Name: 5-phenyl-N-(3-(thiazol-2-yl)propyl)isoxazole-3-carboxamide
• Canonical SMILES: O=C(C1=NOC(C2=CC=CC=C2)=C1)NCCCC3=NC=CS3
• InChI: InChI=1S/C16H15N3O2S/c20-16(18-8-4-7-15-17-9-10-22-15)13-11-14(21-19-13)12-5-2-1-3-6-12/h1-3,5-6,9-11H,4,7-8H2,(H,18,20)
• InChI Key: UFASECSYKSMYET-UHFFFAOYSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: To be determined
• Elemental Analysis: C, 61.32; H, 4.82; N, 13.41; O, 10.21; S, 10.23
• Exact Mass: 313.0885
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).