627-50-9 Purity
0.96
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Specification
In the pharmaceutical field, polyvinylpyrrolidone (PVP) can be used as an adhesive, coating agent, suspending agent, pore-forming agent, solubilizer and stabilizer, etc., thanks to its inert, non-toxic and biocompatible properties. characteristic. PVP of different molecular weights and concentrations can be used in a variety of formulations for different uses. The multifunctional role of PVP in pharmaceutical formulations can mostly be explained by its viscosity, solubility, hydrophilicity and hydrogen bond-forming abilities.
The main applications of PVP in the medical field
· Improve the bioavailability of drugs: keeping amorphous state; increasing surface area; increasing drug wettability.
· Improve the stability of drugs: increasing the viscosity; generating steric barriers; interactions between molecules.
· Improve the physical and mechanical properties: rigid/hygroscopic/hydrophilic properties; surface modification; high plastic deformation.
· Regulate the rate of drug release: pores formation after dissolution; formation of viscous layer.
· Prolong the in vivo circulation time of liposomes.
In colloidal nanoparticle synthesis, polyvinylpyrrolidone (PVP) can be used as a surface stabilizer, growth regulator, nanoparticle dispersant, and reducing agent.
Examples of PVP in colloidal nanoparticle synthesis
· PVP in the synthesis of metallic NPs: PVP is widely used as a stabilizing and shape-directing agent in the polyol synthesis of metallic NPs. Examples of these NPs include plasmonic elements (Ag, Au, Cu), catalytic elements (Pd, Pt), magnetic elements (Co, Ni) and bimetallic compositions (Au-M, PtM).
· PVP in the synthesis of metal oxide NPs: These oxides include compounds as iron oxides, more complex ferrites, as well as other transition metal and main group metal oxides, but also rare-earth metal oxides.
· Metal chalcogenide nanostructures with PVP: PVP serves as an excellent stabilizer and shape-directing agent also during metal chalcogenide (MC) NPs synthesis preventing their aggregation and passivating surface states. Furthermore, the use of PVP can enhance the optical properties of MC NPs under certain conditions.
Colloidal synthesis provides a route to synthesize nanoparticles (NPs) with controlled composition and structural features. There are new approaches to obtain such nanostructures using polyvinylpyrrolidone (PVP). PVP can be used as a surface stabilizer, growth regulator, nanoparticle dispersant, and reducing agent. This dependence stems from the amphiphilic nature of PVP and the molecular weight of the selected PVP. These properties can affect the growth and morphology of nanoparticles by providing solubility in different solvents, selective surface stabilization, and even obtaining kinetically controlled growth conditions. The properties of PVP-capped nanoparticles in terms of surface enhanced Raman spectroscopy (SERS), assembly, catalysis, etc. are discussed. The contribution of PVP to these properties and its removal are considered. Ultimately, NPs obtained by using PVP in colloidal synthesis are opening up new applications.
Pd nanowires and nanorods with 5-fold twinning structures have been synthesized by the hydrothermal reaction of PdCl, NaI, and PVP. Based on HRTEM and ED, it is proposed that the nanowires are bounded by 5 {100} faces and grow along the [110] direction. The average diameter of the Pd NWs is 9.0 nm and the length is micrometers. PVP has a dual role in the synthesis of NWs. The first is to act as a reducing agent through the hydroxyl groups at the end of the molecule. The second role of PVP is to act as a surface protectant to prevent the nanowires from agglomerating together. The PVP concentration is also important because increasing or decreasing its concentration changes the final morphology from wires to spheres and rods or a mixture of triangles, strips, tetrahedrons, and cubes.
Polyvinylpyrrolidone (PVP) is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps encapsulate and contain hydrophilic and lipophilic drugs. These advantages make PVP a versatile excipient in the development of a wide range of traditional to novel controlled release system formulations. Based on different molecular weights and modified forms, PVP can bring specific beneficial properties with different chemical properties. PVP research aims to design systems for drug, gene and cosmetic delivery, etc. The past and growing interest in PVP makes it a promising polymer to enhance the characteristics and performance of contemporary pharmaceutical dosage forms. PVP derivatives such as povidone-iodine (PVP-I) also have importance and role in the design and clinical trials to evaluate the efficacy of treatments against COVID-19 in the current situation.
Hydrogels PVP is widely used in the development of hydrogels due to its swelling properties in aqueous environments. Some researchers used theophylline as a model drug to prepare and characterize cross-linked PVP hydrogels with 3 different compositions (drug: polymer ratio of 1:1, 1:2, 1:3). It was concluded that the increase in PVP concentration reduced the release rate of the drug from the hydrogel-based compacted matrix tablets. A new pH- and electro-sensitive hydrogel was developed using PVP-polyacrylic acid (PAA) copolymers. This pH- and electro-sensitive hydrogel is suitable for sensors, actuators, switches, and drug delivery systems.
Excellent Results with Polyvinylpyrrolidone
I recently used polyvinylpyrrolidone in my cell fixation and immunofluorescence experiments, following the mentioned protocol. I was extremely impressed with the results I achieved. The polyvinylpyrrolidone solution provided excellent stability and allowed for clear and crisp imaging of my target protein. The cells were well-preserved and the background was minimal, resulting in high-quality images. The ease of use and compatibility with other reagents in the protocol made my experiments run smoothly. I highly recommend polyvinylpyrrolidone for any researchers performing similar experiments. Overall, I am extremely satisfied with the results and will continue to use polyvinylpyrrolidone in my future experiments.
Highly Effective Polyvinylpyrrolidone for Intracytoplasmic Injection Treatment
I recently used Polyvinylpyrrolidone (PVP) during my intracytoplasmic injection treatment for zygotes and I must say, the results were outstanding. The PVP solution, diluted in 10%, was easy to work with and provided excellent stability for the embryos during the exposure period. The smooth texture of the PVP made the injection process seamless and precise.
The molecular formula of Polyvinylpyrrolidone is (C6H9NO)n.
Some synonyms for Polyvinylpyrrolidone are PVP, Povidone, and Polyvidone.
The boiling point of Polyvinylpyrrolidone is 90-93 °C.
Polyvinylpyrrolidone has biocompatibility, low toxicity, adhesive characteristics, complexing stability, relatively inert behavior, and is resistant to thermal degradation.
Polyvinylpyrrolidone is useful in a variety of applications such as cosmetics, tissue engineering, and biomedical engineering.
The quality level of Polyvinylpyrrolidone is 200.
The melting point of Polyvinylpyrrolidone is 13.9 °C.
The Autoignition Temperature of Polyvinylpyrrolidone is 240 °C.
Polyvinylpyrrolidone is soluble in water and in ethanol, and insoluble in ether.
Polyvinylpyrrolidone is typically packaged in 250 g or 1 kg bottles.