Specification
Description
Biodegradable and biocompatible PGA could be potentially useful for bone regeneration. High molecular weight polyglycolide (PGA) can be prepared by ring opening polymerization of diglycolide in the presence of diphenyl bismuth bromide.
Synonyms
PGA, Poly(glycolic acid)
IUPAC Name
2-hydroxyacetic acid
Canonical SMILES
OCC(O)=O
InChI
1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
InChI Key
AEMRFAOFKBGASW-UHFFFAOYSA-N
Melting Point
79.5 °C;78-80 °C (alpha-modification); 63 °C (beta-modification, metastable);75-80°C;80 °C
Density
1.53 g/mL at 25 °C (lit.)
Solubility
In water, 1X10+6 mg/L at 25 °C (est);Soluble in ethanol, ethyl ether;Soluble in methanol, acetone, acetic acid;Solubility in water: very good
Application
Polyglycolide (PGA) along with polylactide may be used to prepare a biodegradable copolymer to be used as implantations. Fabrication of biopolymer/carbon nanotube composite has been reported using PGA fiber as one of the constituents of the composite. Modified porous PGA scaffolds has been fabricated.
Color/Form
Colorless, translucent solid;Solid glycolic acid forms colorless, monoclinic, prismatic crystals.;Orthorhombic needles from water; leaves from diethyl ether
Covalently-Bonded Unit Count
1
Decomposition
Hazardous decomposition products formed under fire conditions. - Carbon oxides;When heated to decomposition it emits acrid smoke and irritating fumes.;100 °C
EC Number
201-180-5;217-693-2;247-326-1
Exact Mass
76.016044g/mol
Features And Benefits
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.
LogP
-1.11 (LogP);log Kow = -1.11;-1.11;-1.11
Monoisotopic Mass
76.016044g/mol
Other Experimental
BP: decomposes;MP: 79.5 °C;Hygroscopic;Heat of combustion: 697.1kJ/mole; heat of solution: -11.5 kJ/mole;Light, straw-colored lliquid, odor like burnt sugar; density: 1.27; mp: 10 °C /Commercial 70% solution/;When heated to decomposition it emits acrid smoke and irritating fumes.;Henry's Law constant = 8.5X10-8 atm-cu m/mol at 25 °C (est);Hydroxyl radical reaction rate constant = 3.11X10-12 cu cm/molecule-sec at 25 °C (est)
Packaging
1, 5, 10 g in glass bottle
Stability
Stable under recommended storage conditions.
Storage Temperature
2-8°C
Vapor Density
Relative vapor density (air = 1): 2.6
Vapor Pressure
0.02 mmHg;2.0X10-2 mm Hg at 25 °C (extrapolated)