OX02983

• Catalog Number: ACMA00027300
• Category: Others
• Molecular Weight: 344.41
• Molecular Formula: C22H20N2O2
• Description: OX02983 is a novel anthelmintic agent, immobilising whipworm and reducing the ability of embryonated T. muris eggs to establish infection in the mouse host in vivo. OX02983 is a new class of anthelmintic, active against both egg and adult stages of Trichuris parasites. OX02983 demonstrated encouraging selectivity for the parasite, and importantly show considerable scope for further optimisation to improve potency and pharmacokinetic properties with the aim of developing a clinical agent.
• Synonyms: OX02983; OX-02983; OX 02983
• IUPAC Name: 1-(4-Methyl-benzyl)-7-pyridin-4-yl-1,5-dihydro-benzo[e][1,4]oxazepin-2-one
• Canonical SMILES: O=C1COCC2=CC(C3=CC=NC=C3)=CC=C2N1CC4=CC=C(C)C=C4
• InChI: InChI=1S/C22H20N2O2/c1-16-2-4-17(5-3-16)13-24-21-7-6-19(18-8-10-23-11-9-18)12-20(21)14-26-15-22(24)25/h2-12H,13-15H2,1H3
• InChI Key: WVDDSRCJSCVKDL-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: OX02983 is a novel anthelmintic agent, immobilising whipworm and reducing the ability of embryonated T. muris eggs to establish infection in the mouse host in vivo.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 76.72; H, 5.85; N, 8.13; O, 9.29
• Exact Mass: 344.1525
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: Dihydrobenzoxazepinone OX02983 was able to reduce infectivity in vivo (Tukey's honest significant difference test, P < 0.005), by an estimated 54% (median DMSO control = 12.0 worms establishing infection, median OX02983 treated group = 5.5 worms). These results support the potential use of dihydrobenzoxazepinones as a spray or other treatment that reduces the infectivity of Trichuris eggs within the environment, in particular at hotspots such as latrines.; Reference: PLoS Negl Trop Dis. 2017 Feb 9;11(2):e0005359. https://pubmed.ncbi.nlm.nih.gov/28182663/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).