Osalmid

• CAS: 526-18-1
• Catalog Number: ACM526181
• Category: Inhibitors
• Molecular Weight: 229.23
• Molecular Formula: C₁₃H₁₁NO₃
• Description: Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC50 of 8.23 μM.
• Canonical SMILES: O=C(NC1=CC=C(O)C=C1)C2=CC=CC=C2O
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.

Synthetic Use

Upstream Synthesis Route 1

• 123-30-8
• 65-45-2

• 526-18-1

Reference: [1] Patent: CN105503633, 2016, A, . Location in patent: Paragraph 0006; 0014; 0015

Upstream Synthesis Route 2

• 123-30-8
• 69-72-7

• 526-18-1

Reference: [1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 12, p. 4113 - 4124

Upstream Synthesis Route 3

• 123-30-8
• 118-55-8

• 526-18-1

Reference: [1] Journal fuer Praktische Chemie (Leipzig), 1900, vol. <2> 61, p. 552

Upstream Synthesis Route 4

• 19065-81-7

• 526-18-1

Reference: [1]Journal of Organic Chemistry,1948,vol. 13,p. 796,799

Upstream Synthesis Route 5

• 123-30-8
• 118-55-8

• 526-18-1

Reference: [1]Journal fur praktische Chemie (Leipzig 1954),1900,vol. <2> 61,p. 552
Chemisches Zentralblatt,1900,vol. 71,p. 612
[2]Journal of the American Chemical Society,1947,vol. 69,p. 2913
[3],1930,vol. 21,p. 245T,255T
[4]Journal fur praktische Chemie (Leipzig 1954),1900,vol. <2> 61,p. 552
Chemisches Zentralblatt,1900,vol. 71,p. 612
[5]Journal of the American Chemical Society,1947,vol. 69,p. 2913