Oroxylin A

• CAS: 480-11-5
• Catalog Number: ACM480115
• Category: Inhibitors
• Molecular Weight: 284.26
• Molecular Formula: C16H12O5
• Description: Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells . Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability . Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation .In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well .
• Canonical SMILES: O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: PlantsBignoniaceaeOroxylum indicum (Linn.) Bentham ex Kurz

Synthetic Use

Upstream Synthesis Route 1

• 973-67-1

• 480-11-5

Reference: [1] Chemical and pharmaceutical bulletin, 2003, vol. 51, # 3, p. 339 - 340
[2] Patent: US2004/242907, 2004, A1, . Location in patent: Page 3
[3] Chemistry and Biodiversity, 2015, vol. 12, # 2, p. 259 - 272
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2534 - 2535

Upstream Synthesis Route 2

• 21967-41-9

• 480-11-5

Reference: [1] Patent: CN108456190, 2018, A, . Location in patent: Paragraph 0034; 0035; 0036; 0037

Upstream Synthesis Route 3

• 77-78-1
• 21967-41-9

• 480-11-5

Reference: [1] Patent: TW2018/29392, 2018, A, . Location in patent: Paragraph 0026-0028

Upstream Synthesis Route 4

• 571168-66-6

• 480-11-5
• 632-85-9

Reference: [1]Chemical and pharmaceutical bulletin,2003,vol. 51,p. 339 - 340

Upstream Synthesis Route 5

• 21967-41-9

• 480-11-5

Reference: [1]Current Patent Assignee: CHIA NAN UNIVERSITY OF PHARMACY & SCIENCE - CN108456190, 2018, A
Location in patent: Paragraph 0034; 0035; 0036; 0037