4'-O-Methylbavachalcone

• CAS: 20784-60-5
• Catalog Number: ACM20784605
• Category: Inhibitors
• Molecular Weight: 338.40
• Molecular Formula: C21H22O4
• Description: 4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM.
• Canonical SMILES: O=C(C1=CC(C/C=C(C)\C)=C(OC)C=C1O)/C=C/C2=CC=C(O)C=C2
• Appearance: Solid
• Storage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: PlantsLeguminosaePsoralea corylifolia L.

Synthetic Use

Upstream Synthesis Route 1

• 128961-13-7

• 20784-60-5

Reference: [1] Tetrahedron, 2011, vol. 67, # 29, p. 5346 - 5359

Upstream Synthesis Route 2

• 28448-83-1
• 123-08-0

• 20784-60-5

Reference: [1] Patent: EP1623704, 2006, A1, . Location in patent: Page/Page column 59

Upstream Synthesis Route 3

• 1092462-95-7

• 20784-60-5

Reference: [1] Tetrahedron, 2011, vol. 67, # 29, p. 5346 - 5359

Downstream Synthesis Route 1

• 20784-60-5

• 129097-15-0

Reference: [1]Synthetic Communications,1990,vol. 20,p. 649 - 657
[2]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2006,vol. 45,p. 2574 - 2579

* For details of the synthesis route, please refer to the original source to ensure accuracy.