3-Methyladenine

• CAS: 5142-23-4
• Catalog Number: ACM5142234
• Category: Inhibitors
• Molecular Weight: 149.15
• Molecular Formula: C6H7N5
• Description: 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
• Synonyms: 3-Methylpurin-6-amine
• IUPAC Name: 3-Methyl-7h-purin-6-imine
• Canonical SMILES: CN1C=NC(=N)C2=C1N=CN2
• InChI: InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3,7H,1H3,(H,8,9)
• InChI Key: ZPBYVFQJHWLTFB-UHFFFAOYSA-N
• Boiling Point: 240 °C
• Melting Point: 300 °C(lit.)
• Flash Point: 99 °C
• Density: 1.60 g/cm³
• Appearance: White powder
• Storage: Keep in dark place, sealed in dry, room temperature
• Complexity: 211
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 0
• Exact Mass: 149.07014524
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Monoisotopic Mass: 149.07014524
• Physical State: Powder
• pKa: 6.77±0.20(Predicted)
• Refractive Index: 1.8070
• Rotatable Bond Count: 0
• Topological Polar Surface Area: 68.1 Ų

Custom Q&A

What is the chemical formula of 3-METHYLADENINE?

The chemical formula of 3-METHYLADENINE is C6H7N5.

What is the molecular weight of 3-METHYLADENINE?

The molecular weight of 3-METHYLADENINE is 149.15.

How can 3-METHYLADENINE be stored?

3-METHYLADENINE can be stored in a dark place, sealed in dry conditions, at room temperature.

What is the solubility of 3-METHYLADENINE?

3-METHYLADENINE is soluble in DMSO (up to 3 mg/ml) or in DMF (up to 10 mg/ml).

What is the usage of 3-METHYLADENINE?

3-METHYLADENINE is used as an autophagy inhibitor by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).

What is the general description of 3-METHYLADENINE?

3-METHYLADENINE is described as a widely used cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.

What is the safety information provided for 3-METHYLADENINE?

The Hazard Codes for 3-METHYLADENINE are Xn and the Risk Statements are 22.

What is the boiling point of 3-METHYLADENINE?

The boiling point of 3-METHYLADENINE is 240°C.

How does 3-METHYLADENINE work as an inhibitor?

3-METHYLADENINE inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).