Methotrexate

• CAS: 59-05-2
• Catalog Number: ACM59052
• Category: Other Products
• Molecular Weight: 454.44
• Molecular Formula: C₂₀H₂₂N₈O₅
• Synonyms: METHOTREXATE;METHYLAMINOPTERIN;METHYLAMINOPTERINE;ANTIFOLAN;L-(+)-AMETHOPTERIN;4-AMINO-N 10-METHYLPTEROYL-L-GLUTAMIC ACID;4-AMINO-10-METHYLPTEROYLGLUTAMIC ACID;(+)-4-AMINO-10-METHYLFOLIC ACID
• Melting Point: 195°C
• Appearance: powder
• Application: Antitumor drugs
• Hazard Statements: T,F
• Safety Description: 53-26-36/37-45-36/37/39-36-16
• Standard: Chinese Pharmacopoeia 2015 Edition Part 2
• Supplemental Hazard Statements: H225-H301+H311+H331-H340-H370-H301-H315-H319-H360
• Symbol: GHS02,GHS06,GHS08

Custom Q&A

What is the molecular formula of methotrexate?

The molecular formula of methotrexate is C20H22N8O5.

What is the molecular weight of methotrexate?

The molecular weight of methotrexate is 454.4 g/mol.

What is the IUPAC Name of methotrexate?

The IUPAC Name of methotrexate is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid.

What is the InChIKey of methotrexate?

The InChIKey of methotrexate is FBOZXECLQNJBKD-ZDUSSCGKSA-N.

What is the CAS number of methotrexate?

The CAS number of methotrexate is 59-05-2.

What are some synonyms for methotrexate?

Some synonyms for methotrexate include Amethopterin, Rheumatrex, and Methylaminopterin.

What are some of the roles of methotrexate?

Methotrexate is an antineoplastic agent, an antirheumatic drug, an EC 1.5.1.3 inhibitor, a DNA synthesis inhibitor, an abortifacient, a dermatologic drug, an antimetabolite, and an immunosuppressive agent.

What is the description provided for methotrexate in the reference?

Methotrexate is described as an odorless yellow to orange-brown crystalline powder that interferes with DNA and RNA synthesis.

When was methotrexate granted FDA approval?

Methotrexate was granted FDA approval on 7 December 1953.

How does methotrexate inhibit inflammation and cell division?

Methotrexate inhibits several enzymes responsible for nucleotide synthesis, leading to suppression of inflammation and prevention of cell division.