Limonin

• CAS: 1180-71-8
• Catalog Number: ACM1180718
• Category: Inhibitors
• Molecular Weight: 470.51
• Molecular Formula: C26H30O8
• Description: Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.IC50 Value:Target: HIV; anticancerLimonin is a triterpenoid aglycone that is a bitter principle of citrus fruits. Limonin is chemically induced carcinogenesis inhibitor and HIV-1 replication inhibitor. Limonin has anti-proliferative, proapoptotic activity on several cancer cell lines and inhibits azoxymethane-induced colon cancer in rats. Limonin also inhibits HIV-1 replication in culturedf monocytes, macrophages, and mononuclear cells, perhaps by inhibition of HIV-1 protease activity.
• Synonyms: Evodia lactone
• IUPAC Name: (1R,2R,7S,10R,13R,14R,16S,19S,20S)-19-(Furan-3-yl)-9,9,13,20-tetramethyl-4,8,15,18-tetraoxahexacyclo[11.9.0.02,7.02,10.014,16.014,20]docosane-5,12,17-trione
• Canonical SMILES: CC1(C2CC(=O)C3(C(C24COC(=O)CC4O1)CCC5(C36C(O6)C(=O)OC5C7=COC=C7)C)C)C
• InChI: InChI=1S/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20+,23-,24-,25+,26+/m0/s1
• InChI Key: KBDSLGBFQAGHBE-MSGMIQHVSA-N
• Boiling Point: 67 °C
• Melting Point: 298 °C
• Flash Point: 358 °C
• Density: 1.39±0.1 g/cm³
• Appearance: Powder
• Storage: 2-8 °C
• Complexity: 1010
• Exact Mass: 470.19406791
• Isomeric SMILES: C[C@@]12CC[C@H]3[C@]([C@@]14[C@H](O4)C(=O)O[C@H]2C5=COC=C5)(C(=O)C[C@@H]6[C@@]37COC(=O)C[C@@H]7OC6(C)C)C
• Monoisotopic Mass: 470.19406791
• Refractive Index: 1.602
• Topological Polar Surface Area: 105 Ų