Irinotecan hydrochloride

• CAS: 97682-44-5
• Catalog Number: ACM97682445
• Category: Main Products
• Molecular Weight: 623.14
• Molecular Formula: C₃₃H₃₈N₄O₆·HCl
• Synonyms: 9H-Xanthene-3-carboxylic acid,7-ethoxy-9-oxo; 7-ethoxyxanthone-3-carboxylic acid
• IUPAC Name: Irinotecan
• Canonical SMILES: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
• InChI Key: UWKQSNNFCGGAFS-XIFFEERXSA-N
• Exact Mass: 586.27900

Case Study

Irinotecan Hydrochloride in Synergistic Cancer Treatment: Enhancing Chemotherapy Efficacy with Curcumin Co-Delivery Liposomes

He S, et al. Journal of Drug Delivery Science and Technology, 2024, 98, 105848.

Recent studies have highlighted Irinotecan hydrochloride (IRI) potential when co-delivered with other agents to improve therapeutic outcomes. In particular, curcumin (CUR) has been explored as a sensitizer to enhance the efficacy of IRI. In a study examining co-delivery liposomes (CoIRI/CUR Lipo), CUR was shown to boost IRI's performance by promoting the conversion of IRI into its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), which plays a crucial role in inhibiting tumor cell proliferation. The CoIRI/CUR Lipo formulation not only delivered both drugs synergistically but also increased the tumor uptake, with CUR upregulating key enzymes like Carboxylesterase 2 (CSE 2) and Topoisomerase I (Top I) in cancer cells, enhancing the therapeutic impact. In vitro and in vivo evaluations demonstrated significant anticancer activity, with the liposomal formulation achieving a tumor inhibition rate of 94.43%. These findings emphasize the importance of combining Irinotecan hydrochloride with other bioactive compounds like curcumin for a more effective and targeted treatment strategy, showcasing its application in the development of advanced drug delivery systems for cancer therapy.

Custom Q&A

What is the molecular formula of Irinotecan hydrochloride?

The molecular formula of Irinotecan hydrochloride is C33H39ClN4O6.

What are some synonyms for Irinotecan hydrochloride?

Some synonyms for Irinotecan hydrochloride include Irinotecan Hcl, Topotecin, CPT 11, Camptosar, and Campto.

What is the CAS number for Irinotecan hydrochloride?

The CAS number for Irinotecan hydrochloride is 100286-90-6.

Is Irinotecan hydrochloride an irritant?

Yes, Irinotecan hydrochloride is classified as an irritant.

What is the chemical structure of Irinotecan hydrochloride?

The chemical structure of Irinotecan hydrochloride is shown in the provided images.

Is there an anhydrous form of Irinotecan hydrochloride?

Yes, there is an anhydrous form of Irinotecan hydrochloride.

What is the WHO-DD name for Irinotecan hydrochloride?

The WHO-DD name for Irinotecan hydrochloride is IRINOTECAN HYDROCHLORIDE.

What is the pharmacological classification of Irinotecan hydrochloride?

Irinotecan hydrochloride is classified as a topoisomerase inhibitor.

What is the PubChem CID for Irinotecan hydrochloride?

The PubChem CID for Irinotecan hydrochloride is 11954009.

What is the chemical safety classification of Irinotecan hydrochloride?

Irinotecan hydrochloride is classified as an irritant according to chemical safety guidelines.