Gnetol

• CAS: 86361-55-9
• Catalog Number: ACM86361559
• Category: Inhibitors
• Molecular Weight: 244.2
• Molecular Formula: C14H12O4
• Description: Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities.
• Synonyms: 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;Gnetol
• IUPAC Name: 2-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
• Canonical SMILES: C1=CC(=C(C(=C1)O)C=CC2=CC(=CC(=C2)O)O)O
• InChI: InChI=1S/C14H12O4/c15-10-6-9(7-11(16)8-10)4-5-12-13(17)2-1-3-14(12)18/h1-8,15-18H/b5-4+
• InChI Key: DQULNTWGBBNZSC-SNAWJCMRSA-N
• Appearance: Powder