Glycolic Acid

• CAS: 79-14-1 / 7732-18-5
• Catalog Number: ACM79141
• Category: Material of Cosmetics
• Molecular Weight: 76.05
• Molecular Formula: C2H4O3
• Description: Glycolic acid is a naturally occurring alpha hydroxy acids (or AHAs). Synonym: hydroacetic acid. Concentration: 70% (30% water). Grade: CG
• Synonyms: Acetic acid, 2-hydroxy-
• IUPAC Name: 2-Hydroxyacetic acid
• Canonical SMILES: C(C(=O)O)O
• InChI: AEMRFAOFKBGASW-UHFFFAOYSA-N
• InChI Key: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
• Boiling Point: 112 °C
• Melting Point: 75-80 °C(lit.)
• Flash Point: 128.7ºC
• Density: 1.25g/ml
• Solubility: Water-soluble
• Appearance: Clear, slightly yellowish liquid, characteristic odor
• Application: Peels, creams, lotions, masks, cleansers. Due to it's acidity the final product needs to be tested for safe pH. Optimal pH range from 3.5-5.0. Some over the counter products, after adding glycolic acid, will separate as a result of the low pH, and need to be stabilized.
• Storage: Store light-protected at a cool and dry place
• Active Content: 95%
• Color/Form: Colorless, translucent solid;Solid glycolic acid forms colorless, monoclinic, prismatic crystals.;Orthorhombic needles from water; leaves from diethyl ether
• Complexity: 40.2
• Composition: Glycolic acid, water
• Corrosivity: Corrosive
• Covalently-Bonded Unit Count: 1
• Decomposition: Hazardous decomposition products formed under fire conditions. - Carbon oxides;When heated to decomposition it emits acrid smoke and irritating fumes.;100 °C
• EC Number: 201-180-5;217-693-2;247-326-1
• Exact Mass: 76.016044g/mol
• Features And Benefits: Can reduce the appearance of fine lines, irregular pigmentation, age spots & decreases enlarged poresVery useful in exfoliating products as alpha-hydroxy acid peel, or in creams & lotions at a lower concentration for a more gentle acid-based peelWidely used to rejuvenate the skin by encouraging the shedding of old surface skin cells
• Formal Charge: 0
• Hazard Codes: C
• H-Bond Acceptor: 3
• H-Bond Donor: 2
• Heavy Atom Count: 5
• HS Code: 1518004000
• ICSC Number: 1537
• LogP: -0.93670
• Monoisotopic Mass: 76.016044g/mol
• NSC Number: 166
• Odor: Odorless
• Other Experimental: BP: decomposes;MP: 79.5 °C;Hygroscopic;Heat of combustion: 697.1kJ/mole; heat of solution: -11.5 kJ/mole;Light, straw-colored lliquid, odor like burnt sugar; density: 1.27; mp: 10 °C /Commercial 70% solution/;When heated to decomposition it emits acrid smoke and irritating fumes.;Henry's Law constant = 8.5X10-8 atm-cu m/mol at 25 °C (est);Hydroxyl radical reaction rate constant = 3.11X10-12 cu cm/molecule-sec at 25 °C (est)
• Physical State: Solid
• PSA: 57.53
• Refractive Index: n20/D 1.424
• RIDADR: UN 3265 8/PG 3
• Rotatable Bond Count: 1
• RTECS Number: MC5250000
• Stability: Stable. Incompatible with bases, oxidizing agents and reducing agents.
• UNII: 0WT12SX38S
• UN Number: 3261
• Vapor Density: Relative vapor density (air = 1): 2.6
• Vapor Pressure: 0.02 mmHg;2.0X10-2 mm Hg at 25 °C (extrapolated)
• WGK Germany: 1
• XLogP3: -1.1

Case Study

Biodegradable Polymers Prepared from Glycolic Acid for Biomedical Applications

Swider, Edyta, et al. Acta biomaterialia, 2018, 73, 38-51.

Polylactic-glycolic acid (PLGA) is one of the most widely used biodegradable polymers and can be synthesized by the condensation polymerization of lactic acid and glycolic acid. This typically results in copolymers of low molecular weight and broad molar mass distribution. PLGA can be further prepared into nano/micron particles to meet various biomedical applications.
Preparation and applications of PLGA particles
· Conventional preparation methods include single and double emulsion-solvent evaporation method, nanoprecipitation, spray-drying, emulsification/salting-out, and more.
· New design methods for PLGA particles include microfluidic platforms, membrane extrusion emulsification, and PRINT technique, etc.
· Smart corresponding nanomaterials based on PLGA particles can be used as therapeutic agents, drug carriers and diagnostic agents in the biomedical field.

Custom Q&A

What is the molecular formula of glycolic acid?

The molecular formula of glycolic acid is C2H4O3.

What is the molecular weight of glycolic acid?

The molecular weight of glycolic acid is 76.05 g/mol.

What are some synonyms for glycolic acid?

Some synonyms for glycolic acid are 2-Hydroxyacetic acid, hydroxyacetic acid, and 79-14-1.

What is the IUPAC name of glycolic acid?

The IUPAC name of glycolic acid is 2-hydroxyacetic acid.

What is the InChIKey of glycolic acid?

The InChIKey of glycolic acid is AEMRFAOFKBGASW-UHFFFAOYSA-N.

What is the CAS number of glycolic acid?

The CAS number of glycolic acid is 79-14-1.

What is the UN number of glycolic acid?

The UN number of glycolic acid is 3261.

What is the ChEMBL ID of glycolic acid?

The ChEMBL ID of glycolic acid is CHEMBL252557.

What is the ICSC number of glycolic acid?

The ICSC number of glycolic acid is 1537.

What is the Wikipedia page for glycolic acid?

The Wikipedia page for glycolic acid is Glycolic_acid.