Foscarnet sodium

• CAS: 63585-09-1
• Catalog Number: ACM63585091
• Category: Inhibitors
• Molecular Weight: 191.95
• Molecular Formula: CNa3O5P
• Description: Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis.
• Synonyms: dihydroxyphosphinecarboxylicacidoxidetrisodiumsalt
• Canonical SMILES: O=P(O[Na])(O[Na])C(O[Na])=O
• Appearance: White crystalline powder
• Storage: 4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).
• Shipping: Can be shipped at room temperature, where not in use may vary.

Case Study

Determination Of Related Substances Of Sodium Foscarnet By Hplc

Ming, et al. Herald of Medicine 42.12 (2023): 1830-1834.

Sodium foscarnet is a broad-spectrum non-nucleoside antiviral drug that can non-competitively inhibit HIV reverse transcriptase and hepatitis B virus DNA polymerase. It is clinically used for skin infections and mucosal infections caused by sensitive viruses. To optimize the impurity analysis method of sodium foscarnet. This study used HPLC to simultaneously control impurities I, II and other impurities, simplifying the analysis method, improving the impurity analysis efficiency of sodium foscarnet, and reducing the cost of drug testing.
Take the test solution under sodium foscarnet and divide it into 5 parts. Take 1 mL of each sample.①Add 1 mol/L hydrochloric acid, 0.1 mL of solution, let stand for 1 h, neutralize with 1 mol/L sodium hydroxide solution, and dilute to scale with mobile phase.②Add 0.1 mL of 1 mol/L sodium hydroxide solution, let stand for 1 h, neutralize with 1 mol/L hydrochloric acid solution, and dilute to scale with mobile phase.③Add 0.1 mL of 10% hydrogen peroxide solution, let stand for 1 h, and dilute to scale with mobile phase.④Take the sample solution and expose it to sunlight for 24 h.⑤Take the sample solution and heat it in a water bath at 100℃ for 30 min. The five solutions were tested, and the separation of the chromatogram, degradation product and sodium foscarnet met the requirements.

Custom Q&A

What is the molecular formula of Foscarnet sodium?

The molecular formula of Foscarnet sodium is CNa3O5P.

What are the synonyms of Foscarnet sodium?

The synonyms of Foscarnet sodium are Foscavir, Trisodium phosphonoformate, and Triapten.

What is the molecular weight of Foscarnet sodium?

The molecular weight of Foscarnet sodium is 191.95 g/mol.

What is the parent compound of Foscarnet sodium?

The parent compound of Foscarnet sodium is CID 3415 (Foscarnet).

What are the component compounds of Foscarnet sodium?

The component compounds of Foscarnet sodium are CID 5360545 (Sodium) and CID 4567503 (Phosphonatoformic acid).

What is the description of Foscarnet sodium?

Foscarnet sodium is used as an antiviral agent in the treatment of cytomegalovirus retinitis and as an alternative to ganciclovir for AIDS patients. It is an organic sodium salt and contains a phosphonatoformate.

What is the approved use of Foscarnet sodium by the U.S. FDA?

Foscarnet sodium is approved by the U.S. FDA for the treatment of cytomegalovirus retinitis in individuals with AIDS and for the treatment of acyclovir-resistant mucocutaneous HSV infection in people with weakened immune systems.

How does Foscarnet sodium show activity?

Foscarnet sodium shows activity against human herpesviruses, HIV, and cytomegalovirus retinitis.

What are some other identifiers of Foscarnet sodium?

The CAS number of Foscarnet sodium is 63585-09-1, and it is also identified by the UNII 8C5OQ81LWT.

What is the InChIKey of Foscarnet sodium?

The InChIKey of Foscarnet sodium is DFHAXXVZCFXGOQ-UHFFFAOYSA-K.