Structure

Folic Acid

CAS
59-30-3
Catalog Number
ACM59303-3
Category
Promotional Products
Molecular Weight
441.4
Molecular Formula
C19H19N7O6

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Specification

Description
A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.
Synonyms
Folic acid
IUPAC Name
(2S)-2-[[4-[(2-Amino-4-oxo-3H-Pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
Canonical SMILES
C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N
InChI
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChI Key
OVBPIULPVIDEAO-LBPRGKRZSA-N
Boiling Point
552.35 °C
Melting Point
250 °C
Density
1.4704 g/cm³
Appearance
Solid
Storage
2-8 °C
Complexity
767
Exact Mass
441.13968135
Hazard Codes
Xn
Isomeric SMILES
C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N
MDL Number
MFCD00076077
Monoisotopic Mass
441.13968135
Physical State
Solid
pKa
2.5
Refractive Index
1.6800
Safety Description
24/25
Stability
Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
Topological Polar Surface Area
209 Ų
WGK Germany
1
July 19, 2023


A vitamin
Folic acid has a positive effect on cell division and growth and the synthesis of nutrients.

How stable is folic acid?

Folic acid is stable to visible light, the activity is reduced by ultraviolet light, and the oxidative hydrolysis is accelerated by acid and alkali.

What is the acidity factor of folic acid?

pKa 2.5

What is the chemical structure of folic acid?

The structure of folic acid consists of a nystatin, which is conjugated to nystatin (nystatinyl) adjacent to p-aminobenzoic acid through a methylene bridge, and then combined with glutamic acid.

What is the EC number of folic acid?

200-419-0

What is the form of folic acid??

Yellow to orange crystalline powder

What is the InchI Key of folic acid?

OVBPIULPVIDEAO-LBPRGKRZSA-N

What is the refractive index of folic acid?

1.68

What is the specific optical rotation of folic acid?

20 º (c=1, 0.1N NaOH)

What is the synthesis of folic acid?

Folic acid can be synthesized by first synthesizing the pteridine nucleus and then condensing it with p-aminobenzoylglutamic acid to obtain folic acid, or crude folic acid can be obtained from the reaction of 2,4,5-triamino-6-hydroxypyrimidines, α,β-dibromopropanal, and p-aminobenzoylglutamic acid in acetic acid-sodium acetate buffer solution, which can be refined to obtain folic acid containing two molecules of water of crystallization. Similar to the latter Hop Chemicalbook method, p-aminobenzoylglutamic acid, trichloroacetone and 2,4,5-triamino-6-hydroxypyrimidine sulfate ([1603-20-7]) were cyclized for 6 h in the presence of sodium acetate and sodium metabisulfite, maintaining pH 3.4-3.6, and at a temperature of 36-40°C to give an orange-red folic acid precipitate

What is the way folic acid is absorbed?

Folic acid is absorbed in the body in two ways, actively and diffusely passively, and the site of absorption is mainly in the upper part of the small intestine.

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