Specification
Description
An excellent building block for the preparation of phosphotyrosine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOPand TBTU. Using this reagent, even peptides containing multiple phosphorylation sites have been prepared efficiently by standard Fmoc SPPS methods.
Synonyms
Fmoc-Tyr(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-L-phosphotyrosine
InChI
1S/C31H28NO8P/c33-30(34)29(18-21-14-16-23(17-15-21)40-41(36,37)39-19-22-8-2-1-3-9-22)32-31(35)38-20-28-26-12-6-4-10-24(26)25-11-5-7-13-27(25)28/h1-17,28-29H,18-20H2,(H,32,35)(H,33,34)(H,36,37)/t29-/m0/s1
InChI Key
WNFKGEXQEWKECX-LJAQVGFWSA-N
Application
Peptide synthesis.
Assay
≥90.0% (acidimetric)
≥95% (TLC)
≥95.0% (HPLC)
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
15-25℃
Type
Unusual Amino Acids, Phosphorylated Amino Acids