Specification
Description
The side-chain Mtt group can be selectively removed with 1% TFA in DCM or DCM/HFIP/TFE/TES (6.5:2:1:0.5) , making this an excellent derivative for the synthesis by Fmoc SPPS. of branched peptides, peptides modified at the ornithine side-chain , for the construction of templates and multifunctionalized resins for combinatorial synthesis.
Synonyms
Fmoc-Orn(Mtt)-OH, N-α-Fmoc-N-δ-4-methyltrityl-L-ornithine, Fmoc-(Nd-4-methyltrityl)-L-ornithine
InChI
1S/C40H38N2O4/c1-28-22-24-31(25-23-28)40(29-13-4-2-5-14-29,30-15-6-3-7-16-30)41-26-12-21-37(38(43)44)42-39(45)46-27-36-34-19-10-8-17-32(34)33-18-9-11-20-35(33)36/h2-11,13-20,22-25,36-37,41H,12,21,26-27H2,1H3,(H,42,45)(H,43,44)/t37-/m0/s1
InChI Key
RRYSGISHZIBOJC-QNGWXLTQSA-N
Application
Peptide synthesis.
Assay
≥90.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
15-25℃
Type
Unusual Amino Acids, Analogs of Arginine and Lysine