Fmoc-N-Me-Cys(Trt)-OH

• CAS: 944797-51-7
• Catalog Number: ACM944797517
• Category: Amino Acids
• Molecular Weight: 599.74
• Description: Building block for introduction of N-α-methyl-cysteine amino-acid residues by Fmoc SPPS. Fmoc SPPS of Cysteine-Containing Peptides
• Synonyms: N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine
• InChI: 1S/C38H33NO4S/c1-39(37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34)35(36(40)41)26-44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29/h2-24,34-35H,25-26H2,1H3,(H,40,41)/t35-/m0/s1
• InChI Key: RAKOPMQMPUNRGI-DHUJRADRSA-N
• Melting Point: 234-239℃
• Application: Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).; It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.
• Assay: 97% (HPLC)
• Form: powder or crystals
• Functional Group: Fmoc
• NACRES: NA.26
• Optical Activity: [α]22/D -25.0°, c = 0.5% in dichloromethane
• Quality Level: 100
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-8℃