Specification
Description
The side-chain Mtt group can be selectively removed with 1% TFA in DCM or DCM/HFIP/TFE/TES (6.5:2:1:0.5) , making this an excellent derivative for the synthesis by Fmoc SPPS. of branched peptides, peptides modified at the lysine side-chain , for the construction of templates and multifunctionalized resins for combinatorial synthesis.
Synonyms
Fmoc-Lys(Mtt)-OH, N-α-Fmoc-N-ε-4-methyltrityl-L-lysine
InChI
1S/C41H40N2O4/c1-29-23-25-32(26-24-29)41(30-14-4-2-5-15-30,31-16-6-3-7-17-31)42-27-13-12-22-38(39(44)45)43-40(46)47-28-37-35-20-10-8-18-33(35)34-19-9-11-21-36(34)37/h2-11,14-21,23-26,37-38,42H,12-13,22,27-28H2,1H3,(H,43,46)(H,44,45)/t38-/m0/s1
InChI Key
YPTNAIDIXCOZAJ-LHEWISCISA-N
Application
Peptide synthesis.
Assay
≥95.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Type
Unlabeled Standard Amino Acids, Lysine (Lys)