Fmoc-Cys(Trt)-OH

• CAS: 103213-32-7
• Catalog Number: ACM103213327-1
• Category: Amino Acids
• Molecular Weight: 585.71
• Molecular Formula: C37H31NO4S
• Description: High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. The standard derivative for Fmoc SPPS of peptides containing Cys. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP, is to be employed, it is strongly recommended that collidine is used as the base , as this has been shown to significantly reduce loss of optical integrity during coupling.
• Synonyms: Fmoc-Cys(Trt)-OH, N-α-Fmoc-S-trityl-L-cysteine
• InChI: 1S/C37H31NO4S/c39-35(40)34(38-36(41)42-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-43-37(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,38,41)(H,39,40)/p-1/t34-/m0/s1
• InChI Key: KLBPUVPNPAJWHZ-UMSFTDKQSA-M
• Melting Point: 164-175℃
• Application: Peptide synthesis.
• Assay: ≥98% (TLC); ≥98.0% (acidimetric); ≥99.0% (HPLC)
• Form: powder
• MDL Number: MFCD00038538
• Quality Level: 400
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: -20℃(-15℃to -25℃)
• Type: Unlabeled Standard Amino Acids, Cysteine (Cys)