CAS
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Fmoc-Asp(biotinyl-PEG)-OH
Catalog Number
ACMA00051078
Category
Amino Acids
Molecular Weight
783.93
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Specification
Description
In contrast to Fmoc-Lys(biotin)-OH, this novel biotin-labeled amino acid has excellent solubility in DMF and other solvents used in Fmoc SPPS. The PEG-spacer restricts hindrance between the peptide and avidin, leading to better biotin binding. Furthermore, the hydrophilic nature of the PEG minimizes non-specific interactions that can arise from the spacer group becoming buried in the hydrophobic pocket of proteins.
Associated Protocols and Technical Articles
Biotinylation Reagents for Peptide Synthesis
Literature references
B. Baumeister, et al. (2003) Biopolymers, 71, 339.
Associated Protocols and Technical Articles
Biotinylation Reagents for Peptide Synthesis
Literature references
B. Baumeister, et al. (2003) Biopolymers, 71, 339.
Synonyms
Fmoc-Asp(biotinyl-PEG)-OH, N-α-Fmoc-N-γ-(N-biotinyl-3-(2-(2-(3-aminopropyloxy)-ethoxy)-ethoxy)-propyl)-L-asparagine
Application
Peptide synthesis.
Assay
≥95.0% (HPLC)
≥98% (TLC)
≥98% (TLC)
Form
powder
Functional Group
biotin
Quality Level
200
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
2-8℃
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