Specification
Description
Fmoc-Arg(Me)2-OH is a peptide derivative that consists of two methylated arginines (Me) with an N-terminal Fluorenylmethyloxycarbonyl (Fmoc) group. The Fmoc group is a protective group that is commonly used in peptide synthesis to protect the N-terminus of amino acids from unwanted reactions. Arginine is an amino acid that plays an essential role in protein synthesis, and its importance in biological functions has been well established. The introduction of the Me modification to the arginine molecule has led to significant developments in peptide synthesis.
IUPAC Name
(2S)-5-[[amino(dimethylamino)methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
Canonical SMILES
CN(C)C(=NCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)N
InChI
1S/C23H28N4O4/c1-27(2)22(24)25-13-7-12-20(21(28)29)26-23(30)31-14-19-17-10-5-3-8-15(17)16-9-4-6-11-18(16)19/h3-6,8-11,19-20H,7,12-14H2,1-2H3,(H2,24,25)(H,26,30)(H,28,29)/t20-/m0/s1
InChI Key
QXAXLSMKNHJDNM-FQEVSTJZSA-N
Density
1.28 g/mL at 20 ℃(lit.)
Application
Fmoc-Arg(Me)2-OH has various applications in scientific research. This compound is commonly used in peptide synthesis and has been found to be useful in the preparation of various peptides such as antimicrobial peptides and peptide hormones. Fmoc-Arg(Me)2-OH is also used as a substrate in enzymatic assays and as a modifier in protein labeling.
Type
Unusual Amino Acids, Methylated Amino Acids