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Structure

Fasudil dihydrochloride

CAS
203911-27-7
Catalog Number
ACM203911277
Category
Inhibitors
Molecular Weight
364.29
Molecular Formula
C14H17N3O2S.2ClH
MSDS COA Spec Sheet

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Specification

Description
Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca2+ channel antagonist and vasodilator.
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