Ethyl 2-chloro-1,3-oxazole-4-carboxylate

• CAS: 460081-18-9
• Catalog Number: ACM460081189
• Category: Other Products
• Molecular Weight: 175.57
• Molecular Formula: C₆H₆ClNO₃
• Synonyms: ZINC04198748, Ethyl 2-chlorooxazole-4-carboxylate, CID2763184, E2065M500, 460081-18-9
• IUPAC Name: ethyl 2-chloro-1,3-oxazole-4-carboxylate
• Canonical SMILES: CCOC(=O)C1=COC(=N1)Cl
• InChI Key: SYWQOPRAPDMWMC-UHFFFAOYSA-N
• Boiling Point: 254.1ºC at 760 mmHg
• Flash Point: 107.5ºC
• Density: 1.332g/cm³
• Exact Mass: 175.00400
• Hazard Statements: Xi
• H-Bond Acceptor: 4
• H-Bond Donor: 0

Synthetic Use

Upstream Synthesis Route 1

• 177760-52-0

• 460081-18-9

Reference: [1] Organic Letters, 2003, vol. 5, # 16, p. 2911 - 2914

Upstream Synthesis Route 2

• 70-23-5

• 460081-18-9

Reference: [1] Organic Letters, 2002, vol. 4, # 17, p. 2905 - 2907
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 5764 - 5768
[3] Patent: EP2818473, 2014, A1,
[4] European Journal of Medicinal Chemistry, 2019, p. 80 - 108

Upstream Synthesis Route 3

• 540-80-7
• 177760-52-0
• 7447-39-4

• 460081-18-9

Reference: [1] Patent: US2014/94474, 2014, A1, . Location in patent: Page/Page column

Upstream Synthesis Route 4

• 177760-52-0

• 460081-18-9

Reference: [1]Organic Letters,2003,vol. 5,p. 2911 - 2914

Downstream Synthesis Route 1

• 7486-35-3
• 460081-18-9

• 460081-24-7

Reference: [1]Organic Letters,2002,vol. 4,p. 2905 - 2907

* For details of the synthesis route, please refer to the original source to ensure accuracy.