Eritoran

• CAS: 185955-34-4
• Catalog Number: ACM185955344
• Category: Inhibitors
• Molecular Weight: 1401.59
• Molecular Formula: C₆₆H₁₂₂N₂O₁₉P₂.4Na
• Description: Eritoran is a Toll-like receptor 4 (TLR4) antagonist. Eritoran protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran inhibits pathogenesis of filovirus infection.
• Synonyms: ERITORAN;3-O-Decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate);Eritoran [inn]
• Density: 1.14

Custom Q&A

What is the PubChem CID of Eritoran?

The PubChem CID of Eritoran is 6912404.

What is the molecular formula of Eritoran?

The molecular formula of Eritoran is C66H126N2O19P2.

What is the molecular weight of Eritoran?

The molecular weight of Eritoran is 1313.7 g/mol.

Who is developing Eritoran for the treatment of severe sepsis?

Eritoran is being developed by the Eisai Research Institute of Boston.

What is the mechanism of action of Eritoran?

Eritoran binds to a receptor complex composed of toll-like receptor 4 (TLR4), CD14, and MD2, inhibiting the activation of the receptor complex by lipopolysaccharide (LPS), which may result in the inhibition of pro-inflammatory cytokine secretion and a potentially fatal systemic inflammatory response syndrome (SIRS).

What is the IUPAC name of Eritoran?

The IUPAC name of Eritoran is [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)oxan-2-yl] dihydrogen phosphate.

What is the InChI of Eritoran?

The InChI of Eritoran is InChI=1S/C66H126N2O19P2/c1-7-11-15-19-22-25-26-27-28-29-30-32-34-38-42-46-57(70)67-60-64(82-49-47-54(80-6)45-41-36-18-14-10-4)62(86-88(73,74)75)56(51-79-5)85-65(60)83-52-55-61(72)63(81-48-43-39-35-24-21-17-13-9-3)59(66(84-55)87-89(76,77)78)68-58(71)50-53(69)44-40-37-33-31-23-20-16-12-8-2/h25-26,54-56,59-66,72H,7-24,27-52H2,1-6H3,(H,67,70)(H,68,71)(H2,73,74,75)(H2,76,77,78)/b26-25-/t54-,55-,56-,59-,60-,61-,62-,63-,64-,65-,66-/m1/s1.

What is the Canonical SMILES of Eritoran?

The Canonical SMILES of Eritoran is CCCCCCCCCCCC(=O)CC(=O)NC1C(C(C(OC1OP(=O)(O)O)COC2C(C(C(C(O2)COC)OP(=O)(O)O)OCCC(CCCCCCC)OC)NC(=O)CCCCCCCCCC=CCCCCCC)O)OCCCCCCCCCC.

What is the CAS number of Eritoran?

The CAS number of Eritoran is 185955-34-4.

What is the ChEMBL ID of Eritoran?

The ChEMBL ID of Eritoran is CHEMBL501259.