1,8-Dihydroxy-4,5-dinitroanthraquinone

• CAS: 81-55-0
• Catalog Number: ACM81550
• Category: Inhibitors
• Molecular Weight: 330.21
• Molecular Formula: C₁₄H₆N₂O₈
• Description: 1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM.
• Canonical SMILES: O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O
• Appearance: Solid
• Storage: Powder-20°C, 3 years; In solvent-80°C. 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.