Cytarabine Hydrochloride

• CAS: 69-74-9
• Catalog Number: ACM69749-1
• Category: Inhibitors
• Molecular Weight: 279.68
• Molecular Formula: C9H14ClN3O5
• Description: Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.
• Canonical SMILES: O=C1N=C(C=CN1[C@H]2[C@@H](O)[C@H](O)[C@@H](CO)O2)N.Cl
• Appearance: Solid
• Application: Antitumor drugs
• Storage: 4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Standard: Chinese Pharmacopoeia 2015 Edition Part 2

Synthetic Use

Upstream Synthesis Route 1

• 147-94-4

• 69-74-9

Reference: [1] Patent: US2004/92476, 2004, A1, . Location in patent: Page/Page column 22

Downstream Synthesis Route 1

• 108-24-7
• 69-74-9

• 6742-08-1

Reference: [1]Journal of Medicinal Chemistry,1987,vol. 30,p. 2154 - 2157

Downstream Synthesis Route 2

• 69-74-9

• 17676-65-2

Reference: [1]Journal of Organic Chemistry,1981,vol. 46,p. 2819 - 2823

Downstream Synthesis Route 3

• 69-74-9
• 219797-98-5

• 186594-89-8

Reference: [1]European Journal of Medicinal Chemistry,1998,vol. 33,p. 809 - 816

* For details of the synthesis route, please refer to the original source to ensure accuracy.