Corydaline

• CAS: 518-69-4
• Catalog Number: ACM518694
• Category: Inhibitors
• Molecular Weight: 369.5
• Description: Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
• Synonyms: 2,3,9,10-Tetramethoxy-13-methyl-berbin
• InChI: InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1
• InChI Key: VRSRXLJTYQVOHC-YEJXKQKISA-N
• Melting Point: 135 °C
• Complexity: 503
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Exact Mass: 369.19400834
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 0
• Isomeric SMILES: C[C@@H]1[C@@H]2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
• Monoisotopic Mass: 369.19400834
• Physical State: Powder
• Rotatable Bond Count: 4
• Topological Polar Surface Area: 40.2 Ų