Corilagin

• CAS: 23094-69-1
• Catalog Number: ACM23094691
• Category: Inhibitors
• Molecular Weight: 634.45
• Molecular Formula: C27H22O18
• Description: Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues.
• Synonyms: 1-O-Galloyl-3,6-hexahydroxydiphenol-b-D-Glucopyranose
• IUPAC Name: [(1S,19R,21S,22R,23R)-6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-2,17,20-trioxatetracyclo[17.3.1.04,9.010,15]tricosa-4,6,8,10,12,14-hexaen-21-yl] 3,4,5-trihydroxybenzoate
• Canonical SMILES: C1[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)O)OC(=O)C4=CC(=C(C(=C4C5=C(C(=C(C=C5C(=O)O1)O)O)O)O)O)O)O
• InChI: InChI=1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2/t13-,19-,22-,23+,27+/m1/s1
• InChI Key: TUSDEZXZIZRFGC-XIGLUPEJSA-N
• Boiling Point: 1280.8±65.0 °C
• Melting Point: >200 °C
• Density: 2.11±0.1 g/ml
• Appearance: Powder
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• pKa: 7.53±0.70
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: PlantsEuphorbiaceaePhyllanthus urinaria Linn.

Synthetic Use

Upstream Synthesis Route 1

• 81905-83-1

• 141968-72-1
• 23094-69-1

Reference: [1] Heterocycles, 1992, vol. 33, # 1, p. 375 - 383

Upstream Synthesis Route 2

• 2485-62-3
• 81905-83-1

• 141968-72-1
• 23094-69-1

Reference: [1] Heterocycles, 1992, vol. 33, # 1, p. 375 - 383

Upstream Synthesis Route 3

• 141968-71-0

• 141968-72-1
• 23094-69-1

Reference: [1] Heterocycles, 1992, vol. 33, # 1, p. 375 - 383

Upstream Synthesis Route 4

• 60976-49-0

• 124854-04-2
• 132185-49-0
• 100227-56-3
• 23094-69-1

Reference: [1]Chemical and Pharmaceutical Bulletin,1990,vol. 38,p. 2424 - 2428

Upstream Synthesis Route 5

• 60976-49-0

• 132185-49-0
• 23094-69-1

Reference: [1]Chemical and Pharmaceutical Bulletin,1990,vol. 38,p. 2424 - 2428
[2]Chemical and Pharmaceutical Bulletin,1990,vol. 38,p. 2424 - 2428

Upstream Synthesis Route 6

• 60976-49-0

• 132185-49-0
• 125516-10-1
• 23094-69-1

Reference: [1]Chemical and Pharmaceutical Bulletin,1990,vol. 38,p. 2424 - 2428