Cephalotaxine

• CAS: 24316-19-6
• Catalog Number: ACM24316196-1
• Category: Inhibitors
• Molecular Weight: 315.36
• Molecular Formula: C18H21NO4
• Description: Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity.
• Synonyms: (1S,3aR,14bβ)-1,5,6,8,9,14b-Hexahydro-2-methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1α-ol
• IUPAC Name: (2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-ol
• Canonical SMILES: COC1=C[C@]23CCCN2CCC4=CC5=C(C=C4[C@@H]3[C@@H]1O)OCO5
• InChI: InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1
• InChI Key: YMNCVRSYJBNGLD-KURKYZTESA-N
• Boiling Point: 495.2±45.0 °C
• Melting Point: 131-132 °C
• Density: 1.38±0.1 g/ml
• Appearance: Powder
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Complexity: 523
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Exact Mass: 315.14705815
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Isomeric SMILES: COC1=C[C@]23CCCN2CCC4=CC5=C(C=C4[C@@H]3[C@@H]1O)OCO5
• Monoisotopic Mass: 315.14705815
• Physical State: Solid
• Rotatable Bond Count: 1
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: PlantsTaxaceaeTaxus chinensis (Pilger) Rehd.PlantsIlliciaceaeTaxus chinensis (Pilger) Rehd.PlantsCephalotaxaceaeCephalotaxus fortunei Hooker
• Topological Polar Surface Area: 51.2 Ų

Custom Q&A

What is the chemical formula for CEPHALOTAXINE?

The chemical formula for CEPHALOTAXINE is C21H42O3.

At what temperature does CEPHALOTAXINE melt?

CEPHALOTAXINE melts at a temperature of 131-134°C.

How should CEPHALOTAXINE be stored?

CEPHALOTAXINE should be stored in a refrigerator.

What is the solubility of CEPHALOTAXINE?

CEPHALOTAXINE is soluble in Chloroform and Methanol.

What color is CEPHALOTAXINE in its solid form?

CEPHALOTAXINE is white in color in its solid form.

Where is CEPHALOTAXINE naturally occurring?

CEPHALOTAXINE is a naturally occurring benzazepine alkaloid isolated from Cephalotaxus harringtonia.

What are some uses of cephalotaxine alkaloids?

Cephalotaxine alkaloids are used as an antiangiogenic agent for the treatment of angiogenic diseases and as antiviral and antitumor agents.

What properties have ester derivatives of cephalotaxine shown?

Ester derivatives of cephalotaxine have shown antiviral, antitumor, and anticancer properties.

What are some examples of cephalatoxin esters that have shown significant activity against leukemia?

Examples of cephalatoxin esters include harringtonine, sioharringtonine, and homoharringtonine, which have shown significant activity against leukemia.

What reference discusses the antitumor alkaloids from Cephalotaxus harringtonia?

The antitumor alkaloids from Cephalotaxus harringtonia are discussed in the reference by R. G. Powell, D. Weisleder, C. R. Smith, Jr. (1972) in the Journal of Pharmaceutical Sciences.