Boc-His(Tos)-OH

• CAS: 35899-43-5
• Catalog Number: ACM35899435-1
• Category: Amino Acids
• Molecular Weight: 409.46
• Description: Standard building block for introduction of histidine amino-acid residues by Boc SPPS.
• Synonyms: Boc-His(Tos)-OH, N-α-t.-Boc-N-im-tosyl-L-histidine
• InChI: 1S/C18H23N3O6S/c1-12-5-7-14(8-6-12)28(25,26)21-10-13(19-11-21)9-15(16(22)23)20-17(24)27-18(2,3)4/h5-8,10-11,15H,9H2,1-4H3,(H,20,24)(H,22,23)/t15-/m0/s1
• InChI Key: DCLJSEPKYJSEHW-HNNXBMFYSA-N
• Application: Peptide synthesis.
• Assay: ≥98% (TLC); ≥98.0% (HPLC)
• Form: powder
• Functional Group: Boc
• MDL Number: MFCD00065967
• Quality Level: 200
• Reaction Suitability: reaction type: Boc solid-phase peptide synthesis
• Storage Temperature: 15-25℃

Synthetic Use

Upstream Synthesis Route 1

• 98-59-9
• 17791-52-5

• 35899-43-5

Reference: [1] Journal of Medicinal Chemistry, 1993, vol. 36, # 17, p. 2431 - 2447

Downstream Synthesis Route 1

• 15761-39-4
• 13734-41-3
• 13139-16-7
• 13836-37-8
• 73821-95-1
• 47689-67-8
• 35899-43-5

• 4474-91-3

Reference: [1] Bioorganic Chemistry, 2011, vol. 39, # 2, p. 101 - 109

Downstream Synthesis Route 2

• 2466-76-4
• 13734-34-4
• 13836-37-8
• 35899-43-5

• 110392-39-7

Reference: [1]Journal of Medicinal Chemistry,1987,vol. 30,p. 2126 - 2130

Downstream Synthesis Route 3

• 2466-76-4
• 13734-34-4
• 35899-43-5

• 110392-40-0

Reference: [1]Journal of Medicinal Chemistry,1987,vol. 30,p. 2126 - 2130

Downstream Synthesis Route 4

• 21715-90-2
• 35899-43-5

• 74098-70-7

Reference: [1]Chemical and Pharmaceutical Bulletin,1981,vol. 29,p. 1644 - 1654

* For details of the synthesis route, please refer to the original source to ensure accuracy.