Nicotinamide riboside chloride

• CAS: 23111-00-4
• Catalog Number: ACM23111004
• Category: Main Products
• Molecular Weight: 290.70
• Molecular Formula: C11H15ClN2O5
• Synonyms: 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
• Appearance: White solid

Case Study

Safety And Metabolism Of Long-Term Administration Of Niagen (Nicotinamide Riboside Chloride) In A Randomized, Double-Blind, Placebo-Controlled Clinical Trial In Healthy Overweight Adults

Conze, Dietrich, Charles Brenner, and Claire L. Kruger. Scientific reports 9.1 (2019): 9772.

Nicotinamide riboside (NR) is a newly discovered nicotinamide adenine dinucleotide (NAD) precursor vitamin. The crystalline form of Nicotinamide riboside chloride, known as NIAGeN, is generally regarded as safe for use in food. An 8-week randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the kinetics and dose dependence of the oral efficacy and safety of NR in overweight but healthy men and women. Administration of 100, 300, and 1000 mg NR resulted in dose-dependent and significant increases in whole blood NAD (i.e., 22%, 51%, and 142%) and other NAD metabolites within 2 weeks.
Forty healthy male and female participants participated in a randomized, double-blind, placebo-controlled, parallel study to investigate the safety and health effects of NR (100 mg/day, 300 mg/day, and 1000 mg/day). At the end of the run-in period (day 0), subjects visited the clinic for baseline safety assessments, blood and urine collection, randomization to one of four supplementation groups (placebo, 100 mg, 300 mg, 1000 mg NIAGEN per day; n = 35/group), and additional dietary restriction counseling. Subjects were then released to take their study product for the next 56 days and visited the clinic on days 7, 14, 28, and 56 for safety assessments and blood and urine collection. Prior to the run-in period, visits to the clinic were reviewed for their medical history and health status, and counseling was provided regarding dietary restrictions. At the end of the run-in period (Day 0), subjects visited the clinic for baseline safety assessments, blood and urine collections, randomization to one of four supplementation groups (placebo, 100 mg, 300 mg, 1000 mg NIAGEN daily; n = 35/group), and additional dietary restriction counseling. Subjects were then released to take their study product for the next 56 days and visited the clinic on Days 7, 14, 28, and 56 for safety assessments and blood and urine collections. The study was conducted at KGK Science Inc. Suite 1440, One London Place, 255 Queens Ave, London, Ontario, following Good Clinical Practice (GCP) guidelines and in accordance with ethical principles derived from the Declaration of Helsinki and its subsequent amendments.

Custom Q&A

What is the molecular formula of Nicotinamide riboside chloride?

The molecular formula of Nicotinamide riboside chloride is C11H15ClN2O5.

What are the synonyms for Nicotinamide riboside chloride?

The synonyms for Nicotinamide riboside chloride are Nicotinamide ribose chloride and 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride.

What is the molecular weight of Nicotinamide riboside chloride?

The molecular weight of Nicotinamide riboside chloride is 290.70 g/mol.

What is the parent compound of Nicotinamide riboside chloride?

The parent compound of Nicotinamide riboside chloride is Nicotinamide riboside.

What are the component compounds of Nicotinamide riboside chloride?

The component compounds of Nicotinamide riboside chloride are Hydrochloric Acid and Nicotinamide riboside.

When was Nicotinamide riboside chloride created?

Nicotinamide riboside chloride was created on February 23, 2015.

When was Nicotinamide riboside chloride last modified?

Nicotinamide riboside chloride was last modified on October 21, 2023.

What is the IUPAC name of Nicotinamide riboside chloride?

The IUPAC name of Nicotinamide riboside chloride is 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride.

What is the InChIKey of Nicotinamide riboside chloride?

The InChIKey of Nicotinamide riboside chloride is YABIFCKURFRPPO-IVOJBTPCSA-N.

What is the Canonical SMILES of Nicotinamide riboside chloride?

The Canonical SMILES of Nicotinamide riboside chloride is C1=CC(=C[N+](=C1)C2C(C(C(O2)CO)O)O)C(=O)N.[Cl-].