Abediterol

• CAS: 915133-65-2
• Catalog Number: ACM915133652
• Category: Agonists
• Molecular Weight: 460.52
• Molecular Formula: C25H30F2N2O4
• Description: Abediterol, also known as LAS100977, is a novel potent, long-acting inhaled β(2)-adrenoceptor agonist in development for the treatment of asthma and chronic obstructive pulmonary disease. Abediterol shows subnanomolar affinity for the human β(2)-adrenoceptor and a functional selectivity over β(1)-adrenoceptors higher than that of formoterol and indacaterol in both a cellular model with overexpressed human receptors and isolated guinea pig tissue. Abediterol is a full agonist at the human β(2)-adrenoceptor (E(max) = 91 ± 5% of the maximal effect of isoprenaline). The potency and onset of action that abediterol shows in isolated human bronchi (EC(50) = 1.9 ± 0.4 nM; t½ onset = 7-10 min) is not significantly different from that of formoterol, but its duration of action (t½ ~ 690 min) is similar to that of indacaterol.
• Synonyms: LAS100977; LAS-100977; LAS 100977; Abediterol
• IUPAC Name: 5-((1R)-2-((6-(2,2-Difluoro-2-phenylethoxy)hexyl)amino)-1-hydroxyethyl)-8- hydroxyquinolin-2(1H)-one
• Canonical SMILES: O=C1NC2=C(C([C@@H](O)CNCCCCCCOCC(F)(F)C3=CC=CC=C3)=CC=C2O)C=C1
• InChI: InChI=1S/C25H30F2N2O4/c26-25(27,18-8-4-3-5-9-18)17-33-15-7-2-1-6-14-28-16-22(31)19-10-12-21(30)24-20(19)11-13-23(32)29-24/h3-5,8-13,22,28,30-31H,1-2,6-7,14-17H2,(H,29,32)/t22-/m0/s1
• InChI Key: SFYAXIFVXBKRPK-QFIPXVFZSA-N
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 915133-65-2 (free base); 1044516-17-7 (napadisylate)
• Biological Target: Abediterol, also known as LAS100977, is a novel potent, long-acting inhaled β(2)-adrenoceptor agonist.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 65.20; H, 6.57; F, 8.25; N, 6.08; O, 13.90
• Exact Mass: 460.2174
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).